Human THAP11 Recombinant Protein (RPPB4950)

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SKU:
RPPB4950
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96EK4

Description

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Product Name:Human THAP11 Recombinant Protein
Product Code:RPPB4950
Size:10µg
Species:Human
Target:THAP11
Synonyms:THAP domain-containing protein 11, CTG-B43a, CTG-B45d, HRIHFB2206, RONIN, THAP domain-containing protein 11, THAP11.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The THAP11 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPGFTCC VPGCYNNSHR DKALHFYTFP KDAELRRLWL KNVSRAGVSG CFSTFQPTTG HRLCSVHFQG GRKTYTVRVP TIFPLRGVNE RKVARRPAGA AAARRRQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQSSPSA STAQTAQLQP NLVSASAAVL LTLQATVDSS QAPGSVQPAP ITPTGEDVKP IDLTVQVEFA AAEGAAAAAA ASELQAATAG LEAAECPMGP QLVVVGEEGF PDTGSDHSYS LSSGTTEEEL LRKLNEQRDI LALMEVKMKE MKGSIRHLRL TEAKLREELR EKDRLLAMAV IRKKHGM

THAP Domain Containing, Apoptosis Associated Protein 11 (THAP11) is a part of the thanatos-associated protein family. THAP11 plays a role as a transcriptional repressor and interacts with HCF1 through a coiled coil domain. THAP11 which is localized to the nucleus and cytoplasm takes part in embryogenesis and pluripotency of embryonic stem cells by recruiting epigenetic modifiers.

THAP11 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-314) and having a molecular mass of 36.8kDa.THAP11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:THAP11: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. Belongs to the THAP11 family. Interacts (via coiled coil domain) with HCFC1.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; intercellular bridge; nucleoplasmMolecular Function: DNA binding; protein binding; zinc ion binding
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
UniProt Code:Q96EK4
NCBI GenInfo Identifier:209572685
NCBI Gene ID:57215
NCBI Accession:Q96EK4.2
UniProt Secondary Accession:Q96EK4,O94795, A4UCT5, A8K002
UniProt Related Accession:Q96EK4
Molecular Weight:34,455 Da
NCBI Full Name:THAP domain-containing protein 11
NCBI Synonym Full Names:THAP domain containing 11
NCBI Official Symbol:THAP11��
NCBI Official Synonym Symbols:RONIN; CTG-B43a; CTG-B45d; HRIHFB2206��
NCBI Protein Information:THAP domain-containing protein 11
UniProt Protein Name:THAP domain-containing protein 11
UniProt Synonym Protein Names:
Protein Family:THAP domain-containing protein
UniProt Gene Name:THAP11��
UniProt Entry Name:THA11_HUMAN
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