Description
| Product Name: | Human TGFBRAP1 Recombinant Protein |
| Product Code: | RPPB4944 |
| Size: | 10µg |
| Species: | Human |
| Target: | TGFBRAP1 |
| Synonyms: | TRAP-1, TRAP1, Transforming growth factor-beta receptor-associatedprotein 1, TGF-beta receptor-associated protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TGFBRAP1 protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSKRLQ KEEYHTHLAV LYLEEVLLQR ASASGKGAEA TETQAKLRRLLQKSDLYRVH FLLERLQGAG LPMESAILHG KLGEHEKALH ILVHELQDFA AAEDYCLWCS EGRDPPHRQQLFHTLLAIYL HAGPTAHELA VAAVDLLNRH ATEFDAAQVL QMLPDTWSVQ LLCPFLMGAM RDSIHARRTMQVALGLARSE NLIYTYDKMK LKGSSIQLSD KKLCQICQNP FCEPVFVRYP NGGLVHTHCA ASRHTNPSSSSPGTRT |
TGF-beta receptor-associated protein 1 also knownas TGFBRAP1 takes part in the TGF-beta/activin signaling pathway. TGFBRAP1 isrelated with inactive heteromericTGF-beta and activin receptor complexes, mainlythrough the typeII receptor, and is releasedupon activation of signaling. TGFBRAP1recruits SMAD4 to the vicinity of thereceptor complex and smoothes the progress of its interaction withreceptor-regulated Smads, such as SMAD2.
TGFBRAP1 Human Recombinant produced in E.Coli is asingle, non-glycosylated polypeptide chain containing 296 amino acids (601-860 a.a)and having a molecular mass of 33kDa.TGFBRAP1 is fused to a 36 amino acid His-tag atN-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TGFBRAP1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Belongs to the TRAP1 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q12.1 Cellular Component: early endosome; membrane Molecular Function:protein binding; SMAD binding; transforming growth factor beta receptor binding Biological Process: endosomal vesicle fusion; endosome to lysosome transport; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016] |
| UniProt Code: | Q8WUH2 |
| NCBI GenInfo Identifier: | 74730711 |
| NCBI Gene ID: | 9392 |
| NCBI Accession: | Q8WUH2.1 |
| UniProt Secondary Accession: | Q8WUH2,O60466, A8K5R7, D3DVJ8, |
| UniProt Related Accession: | Q8WUH2 |
| Molecular Weight: | 97,158 Da |
| NCBI Full Name: | Transforming growth factor-beta receptor-associated protein 1 |
| NCBI Synonym Full Names: | transforming growth factor beta receptor associated protein 1 |
| NCBI Official Symbol: | TGFBRAP1�� |
| NCBI Official Synonym Symbols: | VPS3; TRAP1; TRAP-1�� |
| NCBI Protein Information: | transforming growth factor-beta receptor-associated protein 1 |
| UniProt Protein Name: | Transforming growth factor-beta receptor-associated protein 1 |
| Protein Family: | Transforming growth factor-beta receptor-associated protein |
| UniProt Gene Name: | TGFBRAP1�� |
| UniProt Entry Name: | TGFA1_HUMAN |
