Growth Factors & Cytokines Recombinant Proteins
Human TGFB3 Recombinant Protein (RPPB0977)
- SKU:
- RPPB0977
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10600
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human TGFB3 Recombinant Protein |
| Product Code: | RPPB0977 |
| Size: | 5µg |
| Species: | Human |
| Target: | TGFB3 |
| Synonyms: | Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta3. |
| Source: | Nicotiana benthamiana |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution containing 50mM Tris-HCl pH-7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized TGFB3 in sterile 5mM HCl & 50ug/ml BSA at a concentration of 0.05mg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized TGFB3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TGFB3 Human should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | HHHHHALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS |
| Biological Activity: | The biological activity of TGFB3 is measured in culture by its ability to inhibit the mink lung epithelial (Mv1Lu) cells proliferation. ED50 ? 40ng/ml corresponding to a specific activity of 25,000 Units/mg. |
Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.
| UniProt Protein Function: | TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24 Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane Molecular Function:cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome |
| NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P10600 |
| NCBI GenInfo Identifier: | 135684 |
| NCBI Gene ID: | 7043 |
| NCBI Accession: | P10600.1 |
| UniProt Secondary Accession: | P10600,Q8WV88, |
| UniProt Related Accession: | P10600 |
| Molecular Weight: | 35,708 Da |
| NCBI Full Name: | Transforming growth factor beta-3 |
| NCBI Synonym Full Names: | transforming growth factor beta 3 |
| NCBI Official Symbol: | TGFB3�� |
| NCBI Official Synonym Symbols: | ARVD; LDS5; RNHF; ARVD1; TGF-beta3�� |
| NCBI Protein Information: | transforming growth factor beta-3 |
| UniProt Protein Name: | Transforming growth factor beta-3 |
| Protein Family: | Transforming growth factor |
| UniProt Gene Name: | TGFB3�� |
| UniProt Entry Name: | TGFB3_HUMAN |
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