Growth Factors & Cytokines Recombinant Proteins

Human TGFB3 (24-412 a.a.) Recombinant Protein (RPPB0980)

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SKU:
RPPB0980
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P10600
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human TGFB3 (24-412 a.a.) Recombinant Protein
Product Code:RPPB0980
Size:20µg
Species:Human
Target:TGFB3 (24-412 a.a.)
Synonyms:Transforming Growth Factor, Beta 3, Prepro-TransformingGrowth Factor Beta-3, TGF-Beta-3, ARVD1, RNHF, Arrhythmogenic Right VentricularDysplasia 1, Transforming Growth Factor Beta-3, TGF-Beta3, ARVD, Transforminggrowth factor beta-3, TGF-beta-3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TGFB3protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT VMTHVPYQVLALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVEKNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL SFDVTDTVREWLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLILMMIPPHRLDN PGQGGQRKKR ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPYLRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS

Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

TGFB3 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 412 amino acids (24-412 a.a) and having amolecular mass of 47.2kDa.TGFB3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane

Molecular Function:cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding

Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

NCBI Summary:This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
UniProt Code:P10600
NCBI GenInfo Identifier:135684
NCBI Gene ID:7043
NCBI Accession:P10600.1
UniProt Secondary Accession:P10600,Q8WV88,
UniProt Related Accession:P10600
Molecular Weight:35,708 Da
NCBI Full Name:Transforming growth factor beta-3
NCBI Synonym Full Names:transforming growth factor beta 3
NCBI Official Symbol:TGFB3��
NCBI Official Synonym Symbols:ARVD; LDS5; RNHF; ARVD1; TGF-beta3��
NCBI Protein Information:transforming growth factor beta-3
UniProt Protein Name:Transforming growth factor beta-3
Protein Family:Transforming growth factor
UniProt Gene Name:TGFB3��
UniProt Entry Name:TGFB3_HUMAN
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