Growth Factors & Cytokines Recombinant Proteins

Human TGFB3 (207 a.a.) Recombinant Protein (RPPB0979)

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RPPB0979

Description

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Product Name:Human TGFB3 (207 a.a.) Recombinant Protein
Product Code:RPPB0979
Size:5µg
Species:Human
Target:TGFB3 (207 a.a.)
Synonyms:Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:100�l purified human TGF Beta 3protein at 100�g/ml in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Stability:TGF-beta 3 Human Recombinant although stable at 4°C for 1 week, should be stored at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze-thaw cycles.

Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

TGFB3 Human Recombinant protein encoding amino acids 644-850 and total molecular mass of 50 kDa (Including GST Tag).

UniProt Protein Function:TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane

Molecular Function:cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding

Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

NCBI Summary:This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
UniProt Code:P10600
NCBI GenInfo Identifier:135684
NCBI Gene ID:7043
NCBI Accession:P10600.1
UniProt Secondary Accession:P10600,Q8WV88,
UniProt Related Accession:P10600
Molecular Weight:35,708 Da
NCBI Full Name:Transforming growth factor beta-3
NCBI Synonym Full Names:transforming growth factor beta 3
NCBI Official Symbol:TGFB3��
NCBI Official Synonym Symbols:ARVD; LDS5; RNHF; ARVD1; TGF-beta3��
NCBI Protein Information:transforming growth factor beta-3
UniProt Protein Name:Transforming growth factor beta-3
Protein Family:Transforming growth factor
UniProt Gene Name:TGFB3��
UniProt Entry Name:TGFB3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P10600
Research Area:
Growth Factors & Cytokines
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