Human TCEAL7 Recombinant Protein (RPPB4924)

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SKU:
RPPB4924
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BRU2

Description

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Product Name:Human TCEAL7 Recombinant Protein
Product Code:RPPB4924
Size:20µg
Species:Human
Target:TCEAL7
Synonyms:Transcription elongation factor A (SII)-like 7, TCEA-like protein 7, transcription elongation factor A protein-like 7, MGC23947, MPMGp800C04260Q003.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TCEAL7 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMQKPCK ENEGKPKCSV PKREEKRPYG EFERQQTEGN FRQRLLQSLE EFKEDIDYRH FKDEEMTREG DEMERCLEEI RGLRKKFRAL HSNHRHSRDR PYPI

Transcription Elongation Factor A (SII)-Like 7 (TCEAL7) has a role in the negative regulation of NF-kappa-B signaling at the basal level by controlling transcriptional activity of NF-kappa-B on its target gene promoters. TCEAL7 links with cyclin D1 promoter containing Myc E-box sequence and transcriptionally inhibits cyclin D1 expression. TCEAL7 regulates telomerase reverse transcriptase expression and telomerase activity in both alternative lengthening of telomeres (ALT) and telomerase-positive cell lines. TCEAL7 is highly expressed in normal and fetal brain tissues, and weakly expressed in the uterus and ovary. TCEAL7 is down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in the brain and ovarian tumors.

TCEAL7 Human Recombinant produced in E. coli is a single polypeptide chain containing 124 amino acids (1-100) and having a molecular mass of 14.8 kDa.TCEAL7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TCEAL7: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. Belongs to the TFS-II family. TFA subfamily.Chromosomal Location of Human Ortholog: Xq22.1Cellular Component: nucleusBiological Process: transcription, DNA-dependent; inhibition of NF-kappaB transcription factor; negative regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9BRU2
NCBI GenInfo Identifier:23397409
NCBI Gene ID:56849
NCBI Accession:NP_689491.1
UniProt Secondary Accession:Q9BRU2
UniProt Related Accession:Q9BRU2
Molecular Weight:
NCBI Full Name:transcription elongation factor A protein-like 7
NCBI Synonym Full Names:transcription elongation factor A like 7
NCBI Official Symbol:TCEAL7��
NCBI Official Synonym Symbols:WEX5��
NCBI Protein Information:transcription elongation factor A protein-like 7
UniProt Protein Name:Transcription elongation factor A protein-like 7
UniProt Synonym Protein Names:Transcription elongation factor S-II protein-like 7
Protein Family:
UniProt Gene Name:TCEAL7��
UniProt Entry Name:TCAL7_HUMAN
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