Human TBPL1 Recombinant Protein (RPPB4918)

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SKU:
RPPB4918
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62380

Description

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Product Name:Human TBPL1 Recombinant Protein
Product Code:RPPB4918
Size:10µg
Species:Human
Target:TBPL1
Synonyms:TATA box-binding protein-like protein 1, TBP-like protein 1, 21 kDa TBP-like protein, Second TBP of unique DNA protein, STUD, TATA box-binding protein-related factor 2, TBP-related factor 2, TBP-like factor, TBP-related protein, TBPL1, TLF, TLP, TLP21, TRF2, TRP, MGC:8389, MGC:9620.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TBPL1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMDADSDV ALDILITNVV CVFRTRCHLN LRKIALEGAN VIYKRDVGKV LMKLRKPRIT ATIWSSGKII CTGATSEEEA KFGARRLARS LQKLGFQVIF TDFKVVNVLA VCNMPFEIRL PEFTKNNRPH ASYEPELHPA VCYRIKSLRA TLQIFSTGSI TVTGPNVKAV ATAVEQIYPF VFESRKEIL

TBP-Like 1 (TBPL1) is a member of the TBP family. The TATA box-binding protein (TBP) is an indispensable component of the basal transcriptional machinery. TBPL1 is crucial for spermiogenesis and supposed to be significant in expression of developmentally regulated genes.

TBPL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids (1-186 a.a) and having a molecular mass of 23.3kDa.TBPL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TBPL1: Does not bind the TATA box. Has DNA-binding ability. Belongs to the TBP family.
UniProt Protein Details:

Protein type:Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cytoplasm; transcription factor TFIIA complex

Molecular Function:DNA binding; transcription coactivator activity

Biological Process: acrosome formation; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation; spermatid nuclear differentiation; dTTP biosynthetic process

NCBI Summary:This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
UniProt Code:P62380
NCBI GenInfo Identifier:358439409
NCBI Gene ID:9519
NCBI Accession:NP_001240605
UniProt Related Accession:P62380
Molecular Weight:
NCBI Full Name:TATA box-binding protein-like protein 1
NCBI Synonym Full Names:TATA-box binding protein like 1
NCBI Official Symbol:TBPL1��
NCBI Official Synonym Symbols:TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620��
NCBI Protein Information:TATA box-binding protein-like protein 1
UniProt Protein Name:TATA box-binding protein-like protein 1
UniProt Synonym Protein Names:21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein
Protein Family:Protein
UniProt Gene Name:TBPL1��
UniProt Entry Name:TBPL1_HUMAN
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