Human TBCEL Recombinant Protein (RPPB4919)

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RPPB4919

Description

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Product Name:Human TBCEL Recombinant Protein
Product Code:RPPB4919
Size:20µg
Species:Human
Target:TBCEL
Synonyms:Tubulin Folding Cofactor E-Like, E-Like, LRRC351, Leucine Rich Repeat Containing Catastrophin, Tubulin-Specific Chaperone E-Like.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The TBCEL solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMDQPSGR SFMQVLCEKY SPENFPYRRG PGMGVHVPAT PQGSPMKDRL NLPSVLVLNS CGITCAGDEK EIAAFCAHVS ELDLSDNKLE DWHEVSKIVS NVPQLEFLNL SSNPLNLSVL ERTCAGSFSG VRKLVLNNSK ASWETVHMIL QELPDLEELF�LCLNDYETVS CPSICCHSLK LLHITDNNLQ DWTEIRKLGV MFPSLDTLVL ANNHLNAIEE PDDSLARLFP NLRSISLHKS GLQSWEDIDK �LNSFPKLEEV RLLGIPLLQP YTTEERRKLV IARLPSVSKL NGSVVTDGER EDSERFFIRY YVDVPQEEVP FRYHELITKY GKLEPLAEVD�LRPQSSAKVE VHFNDQVEEM SIRLDQTVAE LKKQLKTLVQ LPTSNMLLYY FDHEAPFGPE EMKYSSRALH SFGIRDGDKI YVESKTK

TBCEL, is a factor that is in charge of the microtubule cytoskeleton in determining cell behavior. TBCEL plays a role as a regulator of tubulin stability. While widely expressed in testis, TBCEL is also present in several tissues at a much lower level. TBCEL comprises of seven LRR (leucine-rich) repeats, one LRRCT domain and one ubiquitin-like domain. The gene that translates TBCEL consists of 66,704 bases and maps to human chromosome 11q23.3. Chromosome 11 houses over 1,400 genes and consist of nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that map to chromosome 11.

TBCEL �Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 447 amino acids and having a molecular mass of 50.6kDa.�The TBCEL is purified by proprietary chromatographic techniques.

UniProt Protein Function:LRRC35: Acts as a regulator of tubulin stability.Chromosomal Location of Human Ortholog: 11q23.3Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q5QJ74
NCBI GenInfo Identifier:215273924
NCBI Gene ID:219899
NCBI Accession:Q5QJ74.2
UniProt Secondary Accession:Q5QJ74,Q0VAN6
UniProt Related Accession:Q5QJ74
Molecular Weight:48,195 Da
NCBI Full Name:Tubulin-specific chaperone cofactor E-like protein
NCBI Synonym Full Names:tubulin folding cofactor E like
NCBI Official Symbol:TBCEL��
NCBI Official Synonym Symbols:El; LRRC35��
NCBI Protein Information:tubulin-specific chaperone cofactor E-like protein
UniProt Protein Name:Tubulin-specific chaperone cofactor E-like protein
UniProt Synonym Protein Names:Leucine-rich repeat-containing protein 35
Protein Family:Tubulin-specific chaperone cofactor E-like protein
UniProt Gene Name:TBCEL��
UniProt Entry Name:TBCEL_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q5QJ74
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