Human Tankyrase 1 ELISA Kit

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SKU:
HUFI02906
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
O95271
Sensitivity:
0.188ng/ml
Range:
0.313-20ng/ml
ELISA Type:
Sandwich
Synonyms:
TNKS1, PARP5A, PARPL, pART5, TANK1, TINF1, TNKS, EC 2.4.2.30, PARP-5a, PARP5APARPL, pART5, Poly [ADP-ribose] polymerase 5A, Tankyrase I, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, tankyrase-1, TIN1TANK1, TINF1TNKS-1, TNKS1TRF1
Reactivity:
Human
Research Area:
Cell Cycle

Description

Human Tankyrase 1 ELISA

TNKS1 (Tankyrase) functions as an activator of the Wnt signalling pathway through the mediation of the poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2. These are 2 key components of the beta-catenin destruction complex. this means that poly-ADP-ribosylated target proteins are recognized by RNF146 causing their ubiquitination and resulting degradation. Poly-ADP-ribosyltransferase is a protein that is involved in a number of processes, including the Wnt signalling pathway, telomere length, and vesicle transport. The PARsylation of BLZF1 and CASC3 is mediated by TNKS, this is then followed by the recruitment of RNF146 and subsequent its ubiquitination. In addition, PARsylation of TERK1 is mediated by TNKS, which plays a role in the regulation of telomere length. By regulating the PARsylation of HEPACAM2/MIKI, TKNKS is involved in prometaphase centrosome maturation.TAKS regulates vesicular transport and modulates the subcellular distribution of SLC2A4/GLUT4-vesicles. Spindle pole assembly may utilise TNKS via PARsylation of NUMA1. 26S proteasome activity is increased by TNKS. Lung acinar adenocarcinoma and cherubism are diseases that are associated with TNKS. The metabolism of protein and misspliced GSK3beta mutants stabilize beta-catenin are among the pathways related to TNKS. TNKS is noted in gene ontology annotations of NAD+ and ADP- ribosyltransferase activity. TNKS1 is a homolog of TNKS2.

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