Enzymes Recombinant Proteins

Human TALDO1 Recombinant Protein (RPPB2303)

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RPPB2303

Description

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Product Name:Human TALDO1 Recombinant Protein
Product Code:RPPB2303
Size:25µg
Species:Human
Target:TALDO1
Synonyms:TAL, TAL-H, TALDOR, TALH, TALDO1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:TALDO1 1mg/ml protein solution contains 20 mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSHMSSSPVKRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL AAAQMPAYQE LVEEAIAYGR KLGGSQEDQIKNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGISKDRIL IKLSSTWEGIQAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN TDKKSYEPLE DPGVKSVTKI YNYYKKFSYKTIVMGASFRN TGEIKALAGC DFLTISPKLL GELLQDNAKL VPVLSAKAAQ ASDLEKIHLD EKSFRWLHNEDQMAVEKLSD GIRKFAADAV KLERMLTERM FNAENGK

TALDO1 is a important enzyme of the non-oxidative pentose phosphate pathway supplying ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. TALDO1 delivers a dihydroxyacetone group from donor compounds (fructose 6-phosphate or sedoheptulose 7-phosphate) to aldehyde acceptor compounds. TALDO1 is expressed at selectively great levels in oligodendrocytes of the brain. TALDO1 Deficiency results in accumulation of erythritol, D-arabitol, and ribitol.

TALDO1 Human Recombinant protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 357 amino acids (1-337) and having a molecular mass of 39.7 kDa. TALDO1 is fused to 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.

UniProt Protein Function:TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily.
UniProt Protein Details:

Protein type:Transferase; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:protein binding; transaldolase activity

Biological Process: carbohydrate metabolic process; pentose-phosphate shunt; xylulose biosynthetic process

Disease: Transaldolase Deficiency

NCBI Summary:Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:P37837
NCBI GenInfo Identifier:6648092
NCBI Gene ID:6888
NCBI Accession:P37837.2
UniProt Secondary Accession:P37837,O00751, Q8WV32, Q8WZ45, B2R8M2,
UniProt Related Accession:P37837
Molecular Weight:37,540 Da
NCBI Full Name:Transaldolase
NCBI Synonym Full Names:transaldolase 1
NCBI Official Symbol:TALDO1��
NCBI Official Synonym Symbols:TAL; TALH; TAL-H; TALDOR��
NCBI Protein Information:transaldolase
UniProt Protein Name:Transaldolase
Protein Family:Transaldolase
UniProt Gene Name:TALDO1��
UniProt Entry Name:TALDO_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P37837
Research Area:
Enzymes
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