Human TAGLN3 Recombinant Protein (RPPB4903)

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RPPB4903

Description

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Product Name:Human TAGLN3 Recombinant Protein
Product Code:RPPB4903
Size:20µg
Species:Human
Target:TAGLN3
Synonyms:Transgelin 3, NP22, NP25, Neuronal protein 22, Neuronal protein NP25.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TAGLN3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA ETYGVRTTDI FQTVDLWEGK DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS NKGASQAGMT GYGMPRQIM

TAGLN3 holds a putative Actin-binding domain, two potential phosphorylation sites, two EF-hand motifs and a calponin-homology (CH) domain. TAGLN3 is homologic to transgelin and calponin, two cytoskeleton-interacting proteins. TAGLN3 is a member of the calponin family, and is co-localized with Actin and tubulin, which indicates that TAGLN3 has a part in neuronal plasticity or as a signaling protein. As a result of a wide-ranging expression pattern, TAGLN3 is able to take different roles in the developing and adult brain.

TAGLN3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 219 amino acids (1-199) and having a molecular mass of 24.6 kDa.The TAGLN3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TAGLN3: a cytoskeleton-associated protein that colocalizes with microtubules and actin. Its expression rises incrementally during rat brain development, with highest expression during synaptogenesis. Its expression is altered in the frontal cortex but not the motor cortex of alcoholic human brains. Induced in rat brains during adaptation to ethanol. Contains a CH-domain and a Calponin-domain.
UniProt Protein Details:

Protein type:Actin-binding

Chromosomal Location of Human Ortholog: 3q13.2

Biological Process: central nervous system development

UniProt Code:Q9UI15
NCBI GenInfo Identifier:33860182
NCBI Gene ID:29114
NCBI Accession:Q9UI15.2
UniProt Secondary Accession:Q9UI15,Q96A74, D3DN64,
UniProt Related Accession:Q9UI15
Molecular Weight:22,473 Da
NCBI Full Name:Transgelin-3
NCBI Synonym Full Names:transgelin 3
NCBI Official Symbol:TAGLN3��
NCBI Official Synonym Symbols:NP22; NP24; NP25��
NCBI Protein Information:transgelin-3
UniProt Protein Name:Transgelin-3
UniProt Synonym Protein Names:Neuronal protein 22; NP22; Neuronal protein NP25
Protein Family:Transgelin
UniProt Gene Name:TAGLN3��
UniProt Entry Name:TAGL3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UI15
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