Human TAC1 Recombinant Protein (RPPB4894)
- SKU:
- RPPB4894
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20366
Description
| Product Name: | Human TAC1 Recombinant Protein |
| Product Code: | RPPB4894 |
| Size: | 25µg |
| Species: | Human |
| Target: | TAC1 |
| Synonyms: | Protachykinin-1, PPT, TAC1, NKA, NKNA, TAC2, NK2, NPK, TAC2, Hs.2563. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TAC1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 2M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMEEIGA NDDLNYWSDW YDSDQIKEEL PEPFEHLLQR IARRPKPQQF FGLMGKRDAD SSIEKQVALL KALYGHGQIS HKRHKTDSFV GLMGKRALNS VAYERSAMQN YERRR |
Tachykinin-1 (TAC1) belongs to the tachykinin peptide hormone family. TAC1 are a family of peptides which have similar biologic activities and share a common C-terminal sequence, phe-X-gly-leu-met-NH2, however they have distinct N-terminal sequences that convey receptor specificities. TAC1 is assumed to act as neurotransmitters which interact with nerve receptors and smooth muscle cells. TAC1 induces behavioral responses and serves as vasodilators and secretagogues.
TAC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids (20-129 a.a) and having a molecular mass of 15.6kDa.TAC1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TAC1: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q21-q22 Cellular Component: extracellular space; cell soma; axon; extracellular region; plasma membrane Molecular Function:protein binding; substance P receptor binding Biological Process: tachykinin signaling pathway; negative regulation of heart rate; insemination; response to hormone stimulus; response to morphine; response to lipopolysaccharide; response to pain; sensory perception of pain; positive regulation of saliva secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; cell-cell signaling; positive regulation of acute inflammatory response; positive regulation of lymphocyte proliferation; neuropeptide signaling pathway; regulation of blood pressure; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; positive regulation of ossification; long-term memory |
| NCBI Summary: | This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P20366 |
| NCBI GenInfo Identifier: | 135886 |
| NCBI Gene ID: | 6863 |
| NCBI Accession: | P20366.1 |
| UniProt Related Accession: | P20366 |
| Molecular Weight: | |
| NCBI Full Name: | Protachykinin-1 |
| NCBI Synonym Full Names: | tachykinin precursor 1 |
| NCBI Official Symbol: | TAC1�� |
| NCBI Official Synonym Symbols: | NK2; NPK; NKNA; TAC2; Hs.2563�� |
| NCBI Protein Information: | protachykinin-1 |
| UniProt Protein Name: | Protachykinin-1 |
| UniProt Synonym Protein Names: | PPTCleaved into the following 5 chains:Substance P; Neurokinin A; NKAAlternative name(s):Neuromedin L; Substance K |
| Protein Family: | Splenin |
| UniProt Gene Name: | TAC1�� |
| UniProt Entry Name: | TKN1_HUMAN |
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