Human SYT3 Recombinant Protein (RPPB4888)

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SKU:
RPPB4888
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BQG1

Description

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Product Name:Human SYT3 Recombinant Protein
Product Code:RPPB4888
Size:20µg
Species:Human
Target:SYT3
Synonyms:Synaptotagmin III, SYT3, SytIII, synaptotagmin-3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The SYT3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEFWKLCW VPWRDKGGSA VGGGPLRKDL GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE

Synaptotagmin-3 (SYT3) is a member of the synaptotagmin family. SYT3 is involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may function as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

SYT3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 540 amino acids (76-590) and having a molecular mass of 57.7 kDa.SYT3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SYT3: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle; Calcium-binding

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: synaptic vesicle membrane; integral to membrane; cell junction; endosome

Molecular Function:clathrin binding; syntaxin binding; calcium-dependent phospholipid binding; phosphatidylserine binding; transporter activity; metal ion binding

Biological Process: positive regulation of vesicle fusion; response to calcium ion; calcium ion-dependent exocytosis

UniProt Code:Q9BQG1
NCBI GenInfo Identifier:18202733
NCBI Gene ID:84258
NCBI Accession:Q9BQG1.1
UniProt Secondary Accession:Q9BQG1,Q8N5Z1, Q8N640,
UniProt Related Accession:Q9BQG1
Molecular Weight:63,304 Da
NCBI Full Name:Synaptotagmin-3
NCBI Synonym Full Names:synaptotagmin III
NCBI Official Symbol:SYT3��
NCBI Official Synonym Symbols:SytIII��
NCBI Protein Information:synaptotagmin-3
UniProt Protein Name:Synaptotagmin-3
UniProt Synonym Protein Names:Synaptotagmin III; SytIII
Protein Family:Synaptotagmin
UniProt Gene Name:SYT3��
UniProt Entry Name:SYT3_HUMAN
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