Human SUMO3 Recombinant Protein (RPPB4880)
- SKU:
- RPPB4880
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P55854
Description
| Product Name: | Human SUMO3 Recombinant Protein |
| Product Code: | RPPB4880 |
| Size: | 20µg |
| Species: | Human |
| Target: | SUMO3 |
| Synonyms: | SUMO-3, SMT3A, SMT3H1, SMT3 homolog 1, Small Ubiquitin-related modifier 3, Ubiquitin-like protein SMT3A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The SUMO3 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl,1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GG |
SUMO3 belongs to the SUMO protein family and operates like ubiquitin. Nevertheless, unlike ubiquitin that targets proteins for degradation, SUMO3 protein takes part in several cellular processes, like nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO3 regulates amyloid beta generation and is crucial in the onset or progression of Alzheimer�s disease.
SUMO3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 112 amino acids (1-92a.a.) and having a molecular mass of 12.6kDa (molecular weight on SDS-PAGE will appear higher).SUMO3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SUMO3: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. Expressed predominantly in liver. Belongs to the ubiquitin family. SUMO subfamily. |
| UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: kinetochore; nucleoplasm; PML body; cytoplasm; nucleus Molecular Function:protein binding; SUMO ligase activity Biological Process: cellular protein metabolic process; protein sumoylation; post-translational protein modification |
| NCBI Summary: | This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014] |
| UniProt Code: | P55854 |
| NCBI GenInfo Identifier: | 23503102 |
| NCBI Gene ID: | 6612 |
| NCBI Accession: | P55854.2 |
| UniProt Related Accession: | P55854 |
| Molecular Weight: | |
| NCBI Full Name: | Small ubiquitin-related modifier 3 |
| NCBI Synonym Full Names: | small ubiquitin like modifier 3 |
| NCBI Official Symbol: | SUMO3�� |
| NCBI Official Synonym Symbols: | SMT3A; Smt3B; SMT3H1; SUMO-3�� |
| NCBI Protein Information: | small ubiquitin-related modifier 3 |
| UniProt Protein Name: | Small ubiquitin-related modifier 3 |
| UniProt Synonym Protein Names: | SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A |
| UniProt Gene Name: | SUMO3�� |
| UniProt Entry Name: | SUMO3_HUMAN |
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