Enzymes Recombinant Proteins

Human SULT2B1 Recombinant Protein (RPPB2298)

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RPPB2298

Description

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Product Name:Human SULT2B1 Recombinant Protein
Product Code:RPPB2298
Size:25µg
Species:Human
Target:SULT2B1
Synonyms:SULT2B1, HSST2, EC 2.8.2.2, Sulfotransferase 2B1, Hydroxysteroid sulfotransferase 2, ST2B1, Sulfotransferase family cytosolic 2B member 1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:SULT2B1 Human solution containing 20mM Tris-HCl pH-7.5, & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS LAENTQDVRD DDIFIITYPK SGTTWMIEII CLILKEGDPSWIRSVPIWER APWCETIVGA FSLPDQYSPR LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR DVVVSLYHYS KIAGQLKDPG TPDQFLRDFLKGEVQFGSWF DHIKGWLRMK GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV VAHSTFSAMK ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS PSPGQASETP HPRPS

SULT2B1 catalyzes the sulfate conjugation of numerous hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation enhances the water solubility of molecules, and therefore their renal excretion, however it can also result in bioactivation to form active metabolites. SULT2B1b is localized in the cytosol and nuclei of human cells. SULT2B1b is selective for the sulfation of 3beta-hydroxysteroids such as dehydroepiandrosterone and pregnenolone, and participates in cholesterol sulfation in human skin.

SULT2B1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 365 amino acids (1-365 a.a.) and having a molecular mass of 41.3 kDa. SULT2B1 protein is purified by standard chromatography.

UniProt Protein Function:SULT2B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transferase; Lipid Metabolism - androgen and estrogen; Energy Metabolism - sulfur; EC 2.8.2.2

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; cytosol; nucleus

Molecular Function:protein binding; alcohol sulfotransferase activity; steroid sulfotransferase activity

Biological Process: steroid metabolic process; sulfate assimilation; xenobiotic metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process

NCBI Summary:Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq]
UniProt Code:O00204
NCBI GenInfo Identifier:31563386
NCBI Gene ID:6820
NCBI Accession:NP_814444.1
UniProt Secondary Accession:O00204,O00205, O75814,
UniProt Related Accession:O00204
Molecular Weight:41,308 Da
NCBI Full Name:sulfotransferase family cytosolic 2B member 1 isoform b
NCBI Synonym Full Names:sulfotransferase family, cytosolic, 2B, member 1
NCBI Official Symbol:SULT2B1��
NCBI Official Synonym Symbols:HSST2��
NCBI Protein Information:sulfotransferase family cytosolic 2B member 1; ST2B1; sulfotransferase 2B1; alcohol sulfotransferase; hydroxysteroid sulfotransferase 2
UniProt Protein Name:Sulfotransferase family cytosolic 2B member 1
UniProt Synonym Protein Names:Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2
Protein Family:Sulfotransferase family cytosolic
UniProt Gene Name:SULT2B1��
UniProt Entry Name:ST2B1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00204
Research Area:
Enzymes
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