Enzymes Recombinant Proteins

Human STYX (26-223) Recombinant Protein (RPPB2291)

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SKU:
RPPB2291
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WUJ0
Research Area:
Enzymes

Description

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Product Name:Human STYX (26-223) Recombinant Protein
Product Code:RPPB2291
Size:5µg
Species:Human
Target:STYX (26-223)
Synonyms:Serine/threonine/tyrosine-interacting protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The STYX solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH SHMRREMQEI LPGLFLGPYS SAMKSKLPVL QKHGITHIIC IRQNIEANFI KPNFQQLFRY LVLDIADNPV ENIIRFFPMT KEFIDGSLQM GGKVLVHGNA GISRSAAFVI AYIMETFGMK YRDAFAYVQE RRFCINPNAG FVHQLQEYEA IYLAKLTIQM MSPLQIERSL SVHSGTTGSL KRTHEEEDDF GTMQVATAQN G

STYX is a member of the protein-tyrosine phosphatase family. STYX has a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. Nevertheless, the binding pocket is adequately preserved to bind phosphorylated substrates, and possibly protect them from phosphatases. STYX takes part in spermiogenesis.

STYX Human Recombinant produced in E. coli is a single polypeptide chain containing 221 amino acids (26-223) and having a molecular mass of 25.0kDa.STYX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis.
NCBI Summary:The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
UniProt Code:Q8WUJ0
NCBI GenInfo Identifier:21687043
NCBI Gene ID:6815
NCBI Accession:NP_660294
UniProt Secondary Accession:Q8WUJ0,Q99850, B9EJG0,
UniProt Related Accession:Q8WUJ0
Molecular Weight:25.0 kDa (221aa), confirmed by MALDI-TOF
NCBI Full Name:serine/threonine/tyrosine-interacting protein
NCBI Synonym Full Names:serine/threonine/tyrosine interacting protein
NCBI Official Symbol:STYX��
NCBI Protein Information:serine/threonine/tyrosine-interacting protein
UniProt Protein Name:Serine/threonine/tyrosine-interacting protein
UniProt Synonym Protein Names:Protein tyrosine phosphatase-like protein
Protein Family:Serine/threonine/tyrosine-interacting protein
UniProt Gene Name:STYX��
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