Human STX4 Recombinant Protein (RPPB4868)

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SKU:
RPPB4868
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q12846

Description

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Product Name:Human STX4 Recombinant Protein
Product Code:RPPB4868
Size:20µg
Species:Human
Target:STX4
Synonyms:Syntaxin 4, syntaxin 4A (placental), STX4A, Renal carcinoma antigen NY-REN-31, p35-2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The STX4 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMMRDRT HELRQGDDSS DEEDKERVAL VVHPGTARLG SPDEEFFHKV RTIRQTIVKL GNKVQELEKQ QVTILATPLP EESMKQELQN LRDEIKQLGR EIRLQLKAIE PQKEEADENY NSVNTRMRKT QHGVLSQQFV ELINKCNSMQ SEYREKNVER IRRQLKITNA GMVSDEELEQ MLDSGQSEVF VSNILKDTQV TRQALNEISA RHSEIQQLER SIRELHDIFT FLATEVEMQG EMINRIEKNI LSSADYVERG QEHVKTALEN QKKARKKKVL

Syntaxin 4 (STX4) is a member of the syntaxin/epimorphin family of proteins. The Syntaxin family is cellular receptors for transport vesicles which participate in exocytosis in neutrophils. Syntaxin 4 is vital for normal regulation of�glucose�metabolism uptake in skeletal muscle and decline in STX4 protein levels lead to reduction of whole-body hormone-stimulated glucose metabolism. STX4 is expressed in neutrophils and neutrophil-differentiated HL-60 cells. The STX4 expression in neutrophils increases with differentiation.

STX4 Human Recombinant produced in E. coli is a single polypeptide chain containing 300 amino acids (1-275) and having a molecular mass of 34.7 kDa.STX4 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:STX4: a protein of the syntaxin/epimorphin family. Contains 1 t-SNARE coiled-coil homology domain. Potentially involved in docking of synaptic vesicles at presynaptic active zones. Interacts with SNAP23 and SNAP25BP. Found in a complex with VAMP8 and SNAP23 in pancreas.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; specific granule; cell surface; lateral loop; basolateral plasma membrane; integral to membrane; dendritic spine; trans-Golgi network; cytosol; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; lamellipodium; plasma membrane; vacuole; synapse; intracellular; endosome

Molecular Function:sphingomyelin phosphodiesterase activator activity; SNAP receptor activity; SNARE binding; protein binding

Biological Process: positive regulation of catalytic activity; platelet activation; positive regulation of cell adhesion; organelle fusion; positive regulation of eosinophil degranulation; positive regulation of chemotaxis; positive regulation of immunoglobulin secretion; synaptic vesicle fusion to presynaptic membrane; regulation of exocytosis; intracellular protein transport; response to hydroperoxide; vesicle docking; positive regulation of cell proliferation; post-Golgi vesicle-mediated transport; blood coagulation; positive regulation of cell migration

UniProt Code:Q12846
NCBI GenInfo Identifier:3041737
NCBI Gene ID:6810
NCBI Accession:Q12846.2
UniProt Secondary Accession:Q12846,Q3SWZ3, P70452, Q08850,
UniProt Related Accession:Q12846
Molecular Weight:34180
NCBI Full Name:Syntaxin-4
NCBI Synonym Full Names:syntaxin 4
NCBI Official Symbol:STX4��
NCBI Official Synonym Symbols:STX4A; p35-2��
NCBI Protein Information:syntaxin-4
UniProt Protein Name:Syntaxin-4
UniProt Synonym Protein Names:Renal carcinoma antigen NY-REN-31
UniProt Gene Name:STX4��
UniProt Entry Name:STX4_HUMAN
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