Human STX3 Recombinant Protein (RPPB4867)

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SKU:
RPPB4867
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q13277

Description

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Product Name:Human STX3 Recombinant Protein
Product Code:RPPB4867
Size:20µg
Species:Human
Target:STX3
Synonyms:Syntaxin-3, STX3, STX3A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:STX3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 10% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMMKDRL EQLKAKQLTQ DDDTDAVEIA IDNTAFMDEF FSEIEETRLN IDKISEHVEE AKKLYSIILS APIPEPKTKD DLEQLTTEIK KRANNVRNKL KSMEKHIEED EVRSSADLRI RKSQHSVLSR KFVEVMTKYN EAQVDFRERS KGRIQRQLEI TGKKTTDEEL EEMLESGNPA IFTSGIIDSQ ISKQALSEIE GRHKDIVRLE SSIKELHDMF MDIAMLVENQ GEMLDNIELN VMHTVDHVEK ARDETKKAVK YQSQARKK

Syntaxin 3 (STX3) is a member of the syntaxin family. The syntaxin family members are cellular receptors for transport vesicles which participate in exocytosis in neutrophils. STX3 has a significant role in the growth of neurites and functions as a direct target for omega-6 arachidonic acid. STX3 is steered to the apical membrane of epithelial cells where it forms clusters and is vital in establishing and maintaining polarity required for protein trafficking involving vesicle fusion and exocytosis.

STX3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-263 a.a) and having a molecular mass of 33.2kDa.STX3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:STX3: Potentially involved in docking of synaptic vesicles at presynaptic active zones. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: apical plasma membrane; azurophil granule; growth cone; integral to membrane; intercellular junction; lamellipodium; neuron projection; plasma membrane; SNARE complex; specific granule; synaptic vesicle; vacuole

Molecular Function:arachidonic acid binding; protein binding; SNAP receptor activity; SNARE binding

Biological Process: intracellular protein transport; neurite development; positive regulation of cell adhesion; positive regulation of cell proliferation; positive regulation of chemotaxis; synaptic vesicle fusion to presynaptic membrane; vesicle docking

NCBI Summary:The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Code:Q13277
NCBI GenInfo Identifier:116242806
NCBI Gene ID:6809
NCBI Accession:Q13277.3
UniProt Secondary Accession:Q13277,O43750, O43751, Q15360, B4DME0,
UniProt Related Accession:Q13277
Molecular Weight:32,018 Da
NCBI Full Name:Syntaxin-3
NCBI Synonym Full Names:syntaxin 3
NCBI Official Symbol:STX3��
NCBI Official Synonym Symbols:STX3A��
NCBI Protein Information:syntaxin-3
UniProt Protein Name:Syntaxin-3
Protein Family:Syntaxin
UniProt Gene Name:STX3��
UniProt Entry Name:STX3_HUMAN
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