Human STX2 Recombinant Protein (RPPB4866)

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RPPB4866

Description

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Product Name:Human STX2 Recombinant Protein
Product Code:RPPB4866
Size:10µg
Species:Human
Target:STX2
Synonyms:Syntaxin 2, epimorphin, EPM, EPIM, STX2A, STX2B, STX2C.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The STX2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMMRDRL PDLTACRKND DGDTVVVVEK DHFMDDFFHQ VEEIRNSIDK ITQYVEEVKK NHSIILSAPN PEGKIKEELE DLNKEIKKTA NKIRAKLKAI EQSFDQDESG NRTSVDLRIR RTQHSVLSRK FVEAMAEYNE AQTLFRERSK GRIQRQLEIT GRTTTDDELE EMLESGKPSI FTSDIISDSQ ITRQALNEIE SRHKDIMKLE TSIRELHEMF MDMAMFVETQ GEMINNIERN VMNATDYVEH AKEETKKAIK YQSKARRKK

Syntaxin-2 (STX2) is a member of the syntaxin/epimorphin family of proteins. Syntaxin family members are cellular receptors for transport vesicles which participate in exocytosis in neutrophils. STX2 regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. STX2 is a t-SNARE which localizes to the apical plasma membrane and intracellular vesicular structures. In addition, STX2, along with SNAP-23, is essential for regulated surfactant secretion.

STX2 Human Recombinant produced in E. coli is a single polypeptide chain containing 289 amino acids (1-264) and having a molecular mass of 33.6 kDa.STX2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:STX2: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: basolateral plasma membrane; extracellular space; integral to membrane; intracellular membrane-bound organelle; lamellipodium; plasma membrane; SNARE complex; synaptic vesicle

Molecular Function:calcium-dependent protein binding; protein binding; protein dimerization activity; SNAP receptor activity; SNARE binding

Biological Process: acrosome reaction; ectoderm development; intracellular protein transport; organ morphogenesis; protein oligomerization; regulation of blood coagulation; response to hydroperoxide; signal transduction; synaptic vesicle fusion to presynaptic membrane; vesicle docking

NCBI Summary:The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:P32856
NCBI GenInfo Identifier:292495060
NCBI Gene ID:2054
NCBI Accession:P32856.3
UniProt Secondary Accession:P32856,Q86VW8,
UniProt Related Accession:P32856
Molecular Weight:32,425 Da
NCBI Full Name:Syntaxin-2
NCBI Synonym Full Names:syntaxin 2
NCBI Official Symbol:STX2��
NCBI Official Synonym Symbols:EPM; EPIM; STX2A; STX2B; STX2C��
NCBI Protein Information:syntaxin-2
UniProt Protein Name:Syntaxin-2
UniProt Synonym Protein Names:Epimorphin
Protein Family:Syntaxin
UniProt Gene Name:STX2��
UniProt Entry Name:STX2_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P32856
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