Enzymes Recombinant Proteins
Human Stratifin Recombinant Protein (RPPB2656)
- SKU:
- RPPB2656
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P31947
- Research Area:
- Enzymes
Description
| Product Name: | Human Stratifin Recombinant Protein |
| Product Code: | RPPB2656 |
| Size: | 25µg |
| Species: | Human |
| Target: | Stratifin |
| Synonyms: | 14-3-3 protein sigma, Epithelial cell marker protein 1, HME1, Stratifin, YWHAS, SFN, Stratifin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | Stratifin solution containing 20mM Tris-HCl pH-8, 50mM NaCl and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS |
Stratifin is part of the 14-3-3 family. The 14-3-3 family of proteins plays an important regulatory function in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are 7 isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. Stratifin is an epithelial cell marker that functions as a tumor suppressor whose expression can be down regulated via methylation. Failure of Stratifin expression results in a defective G2/M phase checkpoint and results in epithelial and non-epithelial tumorigenesis.
Stratifin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids (1-248) and having a molecular mass of 27.7 kDa. Stratifin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | 14-3-3 sigma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. Homodimer. Interacts with KRT17 and SAMSN1. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. Belongs to the 14-3-3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: extracellular space; cytoplasmic vesicle membrane; cytoplasm; cytosol; nucleus Molecular Function:protein domain specific binding; protein kinase C inhibitor activity; protein binding; phosphoprotein binding; protein kinase binding Biological Process: positive regulation of protein export from nucleus; regulation of epidermal cell division; release of cytochrome c from mitochondria; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; keratinization; positive regulation of epidermal cell differentiation; negative regulation of protein kinase activity; negative regulation of caspase activity; regulation of cyclin-dependent protein kinase activity; signal transduction; positive regulation of cell growth |
| UniProt Code: | P31947 |
| NCBI GenInfo Identifier: | 398953 |
| NCBI Gene ID: | 2810 |
| NCBI Accession: | P31947.1 |
| UniProt Secondary Accession: | P31947,Q6FH30, Q6FH51, Q96DH0, |
| UniProt Related Accession: | P31947 |
| Molecular Weight: | 24,336 Da |
| NCBI Full Name: | 14-3-3 protein sigma |
| NCBI Synonym Full Names: | stratifin |
| NCBI Official Symbol: | SFN�� |
| NCBI Official Synonym Symbols: | YWHAS�� |
| NCBI Protein Information: | 14-3-3 protein sigma; 14-3-3 sigma; epithelial cell marker protein 1 |
| UniProt Protein Name: | 14-3-3 protein sigma |
| UniProt Synonym Protein Names: | Epithelial cell marker protein 1; Stratifin |
| Protein Family: | 14-3-3 protein |
| UniProt Gene Name: | SFN�� |
| UniProt Entry Name: | 1433S_HUMAN |
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