Human STOM Recombinant Protein (RPPB4853)

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SKU:
RPPB4853
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P27105

Description

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Product Name:Human STOM Recombinant Protein
Product Code:RPPB4853
Size:25µg
Species:Human
Target:STOM
Synonyms:BND7, EPB7, EPB72, Erythrocyte band 7 integral membrane protein, Protein 7.2b, Stomatin, STOM.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The STOM solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSKIIKEYE RAIIFRLGRI LQGGAKGPGL FFILPCTDSF IKVDMRTISF DIPPQEILTK DSVTISVDGV VYYRVQNATL AVANITNADS ATRLLAQTTL RNVLGTKNLS QILSDREEIA HNMQSTLDDA TDAWGIKVER VEIKDVKLPV QLQRAMAAEA EASREARAKV IAAEGEMNAS RALKEASMVI TESPAALQLR YLQTLTTIAA EKNSTIVFPL PIDMLQGIIG AKHSHLG

Stomatin (STOM) is a part of a highly conserved family of integral membrane proteins. STOM is a membrane protein involved in regulation of monovalent cation transport through lipid membranes which regulates ACCN1 and ACCN3 gating. STOM is a major lipid-raft component of erythrocytes and epithelial cells, and an abundant platelet protein which acts as a cytoskeletal anchor.

STOM Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (55-288) and having a molecular mass of 28 kDa. STOM is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:stomatin: Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating. Belongs to the band 7/mec-2 family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytoplasm; cytoskeleton; endoplasmic reticulum; extracellular space; integral to plasma membrane; lipid raft; membrane; mitochondrion; vesicle

Molecular Function:protein binding

Biological Process: positive regulation of defense response to virus by host; protein homooligomerization

Disease: Overhydrated Hereditary Stomatocytosis

NCBI Summary:This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
UniProt Code:P27105
NCBI GenInfo Identifier:114823
NCBI Gene ID:2040
NCBI Accession:P27105.3
UniProt Secondary Accession:P27105,Q14087, Q15609, Q5VX96, Q96FK4, B1AM77,
UniProt Related Accession:P27105
Molecular Weight:13,475 Da
NCBI Full Name:Erythrocyte band 7 integral membrane protein
NCBI Synonym Full Names:stomatin
NCBI Official Symbol:STOM��
NCBI Official Synonym Symbols:BND7; EPB7; EPB72��
NCBI Protein Information:erythrocyte band 7 integral membrane protein
UniProt Protein Name:Erythrocyte band 7 integral membrane protein
UniProt Synonym Protein Names:Protein 7.2b; Stomatin
Protein Family:Stomatin
UniProt Gene Name:STOM��
UniProt Entry Name:STOM_HUMAN
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