Human STMN3 Recombinant Protein (RPPB4851)
- SKU:
- RPPB4851
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NZ72
Description
| Product Name: | Human STMN3 Recombinant Protein |
| Product Code: | RPPB4851 |
| Size: | 10µg |
| Species: | Human |
| Target: | STMN3 |
| Synonyms: | Stathmin-3, SCG10-like protein, STMN3, SCLIP |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | STMN3 Human solution containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDMEVKQLDK RASGQSFEVI LKSPSDLSPE SPMLSSPPKK KDTSLEELQK RLEAAEERRK TQEAQVLKQL AERREHEREV LHKALEENNN FSRQAEEKLN YKMELSKEIR EAHLAALRER LREKELHAAE VRRNKEQREE MSG |
STMN3 is a neuronal specific protein which belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics.
STMN3 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (39-180 a.a.) and having a molecular mass of 18.9 kDa. The STMN3 is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | STMN3: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. Belongs to the stathmin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 20q13.3 Cellular Component: cytoplasm; neuron projection Molecular Function:protein domain specific binding; tubulin binding Biological Process: cytoplasmic microtubule organization and biogenesis; microtubule depolymerization; negative regulation of Rac protein signal transduction; nervous system development; neurite development; regulation of cytoskeleton organization and biogenesis; regulation of GTPase activity |
| NCBI Summary: | This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q9NZ72 |
| NCBI GenInfo Identifier: | 20141809 |
| NCBI Gene ID: | 50861 |
| NCBI Accession: | Q9NZ72.3 |
| UniProt Secondary Accession: | Q9NZ72,O75527, Q969Y4, B3KSQ5, B7WP52, B7Z5G4, |
| UniProt Related Accession: | Q9NZ72 |
| Molecular Weight: | 19,806 Da |
| NCBI Full Name: | Stathmin-3 |
| NCBI Synonym Full Names: | stathmin 3 |
| NCBI Official Symbol: | STMN3�� |
| NCBI Official Synonym Symbols: | SCLIP�� |
| NCBI Protein Information: | stathmin-3 |
| UniProt Protein Name: | Stathmin-3 |
| UniProt Synonym Protein Names: | SCG10-like protein |
| Protein Family: | Stathmin |
| UniProt Gene Name: | STMN3�� |
| UniProt Entry Name: | STMN3_HUMAN |
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