Human STEAP4 Recombinant Protein (RPPB4844)

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RPPB4844

Description

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Product Name:Human STEAP4 Recombinant Protein
Product Code:RPPB4844
Size:20µg
Species:Human
Target:STEAP4
Synonyms:DKFZp666D049, FLJ23153, STAMP2, TIARP, TNFAIP9, Six-transmembraneepithelial antigen of prostate 4, SixTransMembrane protein of prostate 2, Tumornecrosis factor, alpha-induced protein 9.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:STEAP4 protein solution (1mg/ml) contains 20mM Tris-HClbuffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEKT CIDALPLTMN SSEKQETVCI FGTGDFGRSL GLKMLQCGYSVVFGSRNPQK TTLLPSGAEV LSYSEAAKKS GIIIIAIHRE HYDFLTELTE VLNGKILVDI SNNLKINQYPESNAEYLAHL VPGAHVVKAF NTISAWALQS GALDASRQ

STEAP Family Member 4(STEAP4) is a member of the STEAP (six transmembrane epithelial antigen ofprostate) family, resides in the golgi apparatus. STEAP4 act as ametalloreductase which has the ability to reduce both Fe(3+) to Fe(2+) andCu(2+) to Cu(1+),using NAD(+) as acceptor. According to studies in mice andhuman it is possible that STEAP4 may involve in adipocyte development andmetabolism, and also contribute to the normal biology of the prostate cell.

STEAP4 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 188 amino acids (1-152 a.a) andhaving a molecular mass of 20.6kDa.STEAP4 is fused to a 36 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:STEAP4: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; EC 1.16.1.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: Golgi membrane; integral to membrane; plasma membrane; endosome

Molecular Function:metal ion binding; cupric reductase activity

Biological Process: fat cell differentiation; iron ion homeostasis; copper ion import

NCBI Summary:The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
UniProt Code:Q687X5
NCBI GenInfo Identifier:74748242
NCBI Gene ID:79689
NCBI Accession:Q687X5.1
UniProt Secondary Accession:Q687X5,Q658Q9, Q687X4, Q8WWB0, Q9H5R1,
UniProt Related Accession:Q687X5
Molecular Weight:52kDa
NCBI Full Name:Metalloreductase STEAP4
NCBI Synonym Full Names:STEAP family member 4
NCBI Official Symbol:STEAP4��
NCBI Official Synonym Symbols:TIARP; STAMP2; TNFAIP9��
NCBI Protein Information:metalloreductase STEAP4; six transmembrane prostate protein 2; sixTransMembrane protein of prostate 2; tumor necrosis factor, alpha-induced protein 9; six-transmembrane epithelial antigen of prostate 4; tumor necrosis-alpha-induced adipose-related protein
UniProt Protein Name:Metalloreductase STEAP4
UniProt Synonym Protein Names:Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9
Protein Family:Metalloreductase
UniProt Gene Name:STEAP4��
UniProt Entry Name:STEA4_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q687X5
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