Enzymes Recombinant Proteins

Human SSU72 Recombinant Protein (RPPB2285)

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SKU:
RPPB2285
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NP77
Research Area:
Enzymes

Description

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Product Name:Human SSU72 Recombinant Protein
Product Code:RPPB2285
Size:20µg
Species:Human
Target:SSU72
Synonyms:SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae), HSPC182, CTD phosphatase SSU72, Ssu72 RNA polymerase II CTD phosphatase homolog (yeast), PNAS-120, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, EC 3.1.3.16.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SSU72 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPSSPLR VAVVCSSNQN RSMEAHNILS KRGFSVRSFG TGTHVKLPGP APDKPNVYDF KTTYDQMYND LLRKDKELYT QNGILHMLDR NKRIKPRPER FQNCKDLFDL ILTCEERVYD QVVEDLNSRE QETCQPVHVV NVDIQDNHEE ATLGAFLICE LCQCIQHTED MENEIDELLQ EFEEKSGRTF LHTVCFY

SSU72 is an extremely conserved homologue of yeast Ssu72, a CTD phosphatase and a component of the polyadenylation/termination machinery. SSU72 interacts with TFIIB, Rb and DNAM-1 and operates to catalyze the dephosphorylation of target proteins, and taking part in RNA processing and termination via dephosphorylation of Pol II. SSU72 is found in multiple alternatively spliced isoforms.

SSU72 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 217 amino acids (1-194) and having a molecular mass of 25.0kDa.SSU72 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SSU72: May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Belongs to the SSU72 phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Phosphatase; EC 3.1.3.16Chromosomal Location of Human Ortholog: 1p36.33Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; CTD phosphatase activityBiological Process: mRNA polyadenylation
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9NP77
NCBI GenInfo Identifier:74752877
NCBI Gene ID:29101
NCBI Accession:Q9NP77.1
UniProt Secondary Accession:Q9NP77,Q9BZS6, Q9H933
UniProt Related Accession:Q9NP77
Molecular Weight:16,931 Da
NCBI Full Name:RNA polymerase II subunit A C-terminal domain phosphatase SSU72
NCBI Synonym Full Names:SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
NCBI Official Symbol:SSU72��
NCBI Official Synonym Symbols:HSPC182; PNAS-120��
NCBI Protein Information:RNA polymerase II subunit A C-terminal domain phosphatase SSU72; CTD phosphatase SSU72
UniProt Protein Name:RNA polymerase II subunit A C-terminal domain phosphatase SSU72
UniProt Synonym Protein Names:
Protein Family:RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Gene Name:SSU72��
UniProt Entry Name:SSU72_HUMAN
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