Enzymes Recombinant Proteins
Human SSU72 Recombinant Protein (RPPB2285)
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- SKU:
- RPPB2285
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NP77
- Research Area:
- Enzymes
Description
| Product Name: | Human SSU72 Recombinant Protein |
| Product Code: | RPPB2285 |
| Size: | 20µg |
| Species: | Human |
| Target: | SSU72 |
| Synonyms: | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae), HSPC182, CTD phosphatase SSU72, Ssu72 RNA polymerase II CTD phosphatase homolog (yeast), PNAS-120, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, EC 3.1.3.16. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SSU72 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPSSPLR VAVVCSSNQN RSMEAHNILS KRGFSVRSFG TGTHVKLPGP APDKPNVYDF KTTYDQMYND LLRKDKELYT QNGILHMLDR NKRIKPRPER FQNCKDLFDL ILTCEERVYD QVVEDLNSRE QETCQPVHVV NVDIQDNHEE ATLGAFLICE LCQCIQHTED MENEIDELLQ EFEEKSGRTF LHTVCFY |
SSU72 is an extremely conserved homologue of yeast Ssu72, a CTD phosphatase and a component of the polyadenylation/termination machinery. SSU72 interacts with TFIIB, Rb and DNAM-1 and operates to catalyze the dephosphorylation of target proteins, and taking part in RNA processing and termination via dephosphorylation of Pol II. SSU72 is found in multiple alternatively spliced isoforms.
SSU72 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 217 amino acids (1-194) and having a molecular mass of 25.0kDa.SSU72 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SSU72: May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Belongs to the SSU72 phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Phosphatase; EC 3.1.3.16Chromosomal Location of Human Ortholog: 1p36.33Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; CTD phosphatase activityBiological Process: mRNA polyadenylation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NP77 |
| NCBI GenInfo Identifier: | 74752877 |
| NCBI Gene ID: | 29101 |
| NCBI Accession: | Q9NP77.1 |
| UniProt Secondary Accession: | Q9NP77,Q9BZS6, Q9H933 |
| UniProt Related Accession: | Q9NP77 |
| Molecular Weight: | 16,931 Da |
| NCBI Full Name: | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 |
| NCBI Synonym Full Names: | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) |
| NCBI Official Symbol: | SSU72�� |
| NCBI Official Synonym Symbols: | HSPC182; PNAS-120�� |
| NCBI Protein Information: | RNA polymerase II subunit A C-terminal domain phosphatase SSU72; CTD phosphatase SSU72 |
| UniProt Protein Name: | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 |
| UniProt Synonym Protein Names: | |
| Protein Family: | RNA polymerase II subunit A C-terminal domain phosphatase |
| UniProt Gene Name: | SSU72�� |
| UniProt Entry Name: | SSU72_HUMAN |
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