Human SSSCA1 Recombinant Protein (RPPB4834)

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SKU:
RPPB4834
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60232

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human SSSCA1 Recombinant Protein
Product Code:RPPB4834
Size:10µg
Species:Human
Target:SSSCA1
Synonyms:Sjogren Syndrome/Scleroderma Autoantigen 1, Sjogren'SSyndrome/Scleroderma Autoantigen 1, Autoantigen P27, Centromeric Autoantigen(27kD), p27, Sjoegren Syndrome/Scleroderma Autoantigen 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SSSCA1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMALNGAE VDDFSWEPPT EAETKVLQAR RERQDRISRL MGDYLLRGYRMLGETCADCG TILLQDKQRK IYCVACQELD SDVDKDNPAL NAQAALSQAR EHQLASASEL PLGSRPAPQPPVPRPEHCEG AAAGLKAAQG PPAPAVPPNT DVMACTQTAL LQKLTWASAE LGSSTSLETS IQLCGLIRAC AEALRSLQQL QH

Sjogrensyndrome/scleroderma autoantigen 1, SSSCA1 is involved in mitosis. SSSCA1 is acentromere-associated protein which can induce anti-centromereantibodies. In addition SSSCA1 is recognized by a subset of anti-centromere antibodies from patients with scleroderma and Sjogren'ssyndrome.

SSSCA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (1-199aa) and having a molecular mass of 23.9kDa. SSSCA1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SSSCA1: Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 11q13.1

Molecular Function:protein binding

NCBI Summary:This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]
UniProt Code:O60232
NCBI GenInfo Identifier:5902701
NCBI Gene ID:10534
NCBI Accession:O60232.1
UniProt Related Accession:O60232
Molecular Weight:21,474 Da
NCBI Full Name:Sjoegren syndrome/scleroderma autoantigen 1
NCBI Synonym Full Names:Sjogren syndrome/scleroderma autoantigen 1
NCBI Official Symbol:SSSCA1��
NCBI Official Synonym Symbols:p27��
NCBI Protein Information:Sjoegren syndrome/scleroderma autoantigen 1
UniProt Protein Name:Sjoegren syndrome/scleroderma autoantigen 1
UniProt Synonym Protein Names:Autoantigen p27
Protein Family:Sjoegren syndrome/scleroderma autoantigen
UniProt Gene Name:SSSCA1��
UniProt Entry Name:SSA27_HUMAN
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