Human SSBP1 Recombinant Protein (RPPB4829)

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SKU:
RPPB4829
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q04837

Description

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Product Name:Human SSBP1 Recombinant Protein
Product Code:RPPB4829
Size:20µg
Species:Human
Target:SSBP1
Synonyms:Mt-SSB, mtSSB, SOSS-B1, SSBP, PWP1-interacting protein 17, Single-stranded DNA-binding protein, mitochondrial.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SSBP1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSESETTTS LVLERSLNRV HLLGRVGQDP VLRQVEGKNP VTIFSLATNE MWRSGDSEVY QLGDVSQKTT WHRISVFRPG LRDVAYQYVK KGSRIYLEGK IDYGEYMDKN NVRRQATTII ADNIIFLSDQ TKEKE

Single-Stranded DNA Binding Protein 1 (SSBP) participates in mitochondrial biogenesis. SSBP binds preferentially and cooperatively to ss-DNA. The SSBP protein is involved in mitochondrial DNA replication and associates with mitochondrial DNA.

SSBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (17-148 a.a.) and having a molecular mass of 17kDa.SSBP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SSBP1: This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.
UniProt Protein Details:

Protein type:RNA-binding; Mitochondrial

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: mitochondrion; mitochondrial matrix; nucleus

Molecular Function:protein binding; chromatin binding; single-stranded DNA binding

Biological Process: positive regulation of helicase activity; mitochondrion organization and biogenesis; organelle organization and biogenesis; DNA replication

NCBI Summary:SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
UniProt Code:Q04837
NCBI GenInfo Identifier:417811
NCBI Gene ID:6742
NCBI Accession:Q04837.1
UniProt Related Accession:Q04837
Molecular Weight:148
NCBI Full Name:Single-stranded DNA-binding protein, mitochondrial
NCBI Synonym Full Names:single-stranded DNA binding protein 1, mitochondrial
NCBI Official Symbol:SSBP1��
NCBI Official Synonym Symbols:SSBP; mtSSB; Mt-SSB; SOSS-B1��
NCBI Protein Information:single-stranded DNA-binding protein, mitochondrial; PWP1-interacting protein 17
UniProt Protein Name:Single-stranded DNA-binding protein, mitochondrial
UniProt Synonym Protein Names:PWP1-interacting protein 17
UniProt Gene Name:SSBP1��
UniProt Entry Name:SSBP_HUMAN
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