Human SRI Recombinant Protein (RPPB4825)

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SKU:
RPPB4825
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P30626

Description

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Product Name:Human SRI Recombinant Protein
Product Code:RPPB4825
Size:20µg
Species:Human
Target:SRI
Synonyms:Sorcin, 22 kDa protein, CP-22, CP22, V19, SRI, SCN, FLJ26259.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SRI solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.2M NaCl, 1mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAYPGHP GAGGGYYPGG YGGAPGGPAF PGQTQDPLYG YFAAVAGQDG QIDADELQRC LTQSGIAGGY KPFNLETCRL MVSMLDRDMS GTMGFNEFKE LWAVLNGWRQ HFISFDTDRS GTVDPQELQK ALTTMGFRLS PQAVNSIAKR YSTNGKITFD DYIACCVKLR ALTDSFRRRD TAQQGVVNFP YDDFIQCVMS V

Sorcin (SRI) which is a 22kDa calcium-binding protein was originally identified in multidrug-resistant cells. Sorcin, which modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum.

SRI Human Recombinant fused with a�23 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�221 amino acids (1-198 a.a.) and having a molecular mass of 24.1kDa. The SRI is purified by proprietary chromatographic techniques.

UniProt Protein Function:SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; membrane; mitochondrion; sarcoplasmic reticulum; T-tubule; cytoplasm; nerve terminal; cytosol; Z disc

Molecular Function:protein binding; protease binding; protein heterodimerization activity; calcium channel regulator activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; receptor binding

Biological Process: regulation of action potential; cytoplasmic sequestering of transcription factor; muscle development; negative regulation of heart rate; heart development; regulation of striated muscle contraction; regulation of calcium ion transport; proteolysis; signal transduction; regulation of heart contraction; transport; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; intracellular sequestering of iron ion

NCBI Summary:This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
UniProt Code:P30626
NCBI GenInfo Identifier:267021
NCBI Gene ID:6717
NCBI Accession:P30626.1
UniProt Secondary Accession:P30626,A8MTH6, B4DKK2, D6W5Q0,
UniProt Related Accession:P30626
Molecular Weight:198
NCBI Full Name:Sorcin
NCBI Synonym Full Names:sorcin
NCBI Official Symbol:SRI��
NCBI Official Synonym Symbols:SCN; V19; CP22; CP-22��
NCBI Protein Information:sorcin; H_RG167B05.1; 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells
UniProt Protein Name:Sorcin
UniProt Synonym Protein Names:22 kDa protein; CP-22; CP22; V19
UniProt Gene Name:SRI��
UniProt Entry Name:SORCN_HUMAN
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