Human SRA1 Recombinant Protein (RPPB4817)
- SKU:
- RPPB4817
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HD15
Description
| Product Name: | Human SRA1 Recombinant Protein |
| Product Code: | RPPB4817 |
| Size: | 10µg |
| Species: | Human |
| Target: | SRA1 |
| Synonyms: | pp7684, SRA, SRAP, STRAA1, Steroid receptor RNA activator 1,Steroid receptor RNA activator protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SRA1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) , 0.1MNaCl ,10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVGSGPAS GVEPTSFPVE SEAVMEDVLR PLEQALEDCR GHTRKQVCDD ISRRLALLQE QWAGGKLSIP VKKRMALLVQ ELSSHRWDAA DDIHRSLMVD HVTEVSQWMV GVKRLIAEKR SLFSEEAANE EKSAATAEKN HTIPGFQQAS |
Steroid receptor RNA activator 1 (SRA1) occurs as both an RNA transcript and as constantly expressed proteins. In addition, SRA1 mediates transcriptional coactivation of steroid receptors ligand-dependently via the steroid-binding domain (AF-2). SRA1 augments cellular proliferation and differentiation and stimulates apoptosis in vivo. SRA1 has a role in tumorigenesis. SRA1 participates in some activities such as: metabolism, adipogenesis and chromatin organization.
SRA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 170 amino acids (90-236 a.a.) and having a molecular mass of 18.7kDa.SRA1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SRA1: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Belongs to the SRA1 family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: nucleoplasm; microtubule cytoskeleton; intercellular bridge; cytoplasm; plasma membrane; nucleus; ribonucleoprotein complex Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity Biological Process: regulation of apoptosis; cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; cell differentiation |
| NCBI Summary: | Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q9HD15 |
| NCBI GenInfo Identifier: | 74718904 |
| NCBI Gene ID: | 10011 |
| NCBI Accession: | Q9HD15.1 |
| UniProt Secondary Accession: | Q9HD15,Q6NVU9, Q8IXM1, Q9HD13, Q9HD14, |
| UniProt Related Accession: | Q9HD15 |
| Molecular Weight: | 25,673 Da |
| NCBI Full Name: | Steroid receptor RNA activator 1 |
| NCBI Synonym Full Names: | steroid receptor RNA activator 1 |
| NCBI Official Symbol: | SRA1�� |
| NCBI Official Synonym Symbols: | SRA; SRAP; STRAA1; pp7684�� |
| NCBI Protein Information: | steroid receptor RNA activator 1; SRA1; steroid receptor coactivator; steroid receptor RNA activator protein; steroid receptor RNA activator 1 (complexes with NCOA1) |
| UniProt Protein Name: | Steroid receptor RNA activator 1 |
| UniProt Synonym Protein Names: | Steroid receptor RNA activator protein; SRAP |
| Protein Family: | Steroid receptor RNA activator |
| UniProt Gene Name: | SRA1�� |
| UniProt Entry Name: | SRA1_HUMAN |
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