Human SPSB1 Recombinant Protein (RPPB4814)
- SKU:
- RPPB4814
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96BD6
Description
| Product Name: | Human SPSB1 Recombinant Protein |
| Product Code: | RPPB4814 |
| Size: | 10µg |
| Species: | Human |
| Target: | SPSB1 |
| Synonyms: | SPRY domain-containing SOCS box protein 1, SSB-1, SPSB1, SSB1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SPSB1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MQELQGLDYC KPTRLDLLLD MPPVSYDVQL LHSWNNNDRS LNVFVKEDDK LIFHRHPVAQ STDAIRGKVG YTRGLHVWQI TWAMRQRGTH AVVGVATADA PLHSVGYTTL VGNNHESWGW DLGRNRLYHD GKNQPSKTYP AFLEPDETFI VPDSFLVALD MDDGTLSFIV DGQYMGVAFR GLKGKKLYPV VSAVWGHCEI RMRYLNGLDP E |
SPRY domain-containing SOCS box protein 1 (SPSB1) belongs to the SOCS box protein subfamily. SPSB1 includes a central SPRY domain and a C-terminal SOCS box. Even though, some of the SOCS protein subfamilies function as adaptors for a large family of ubiquitin-protein isopeptide ligases to regulate certain signaling pathways, the function of the SSB subfamily remains to be determined. SPSB1 may have an imperative role in enhancing the HGF-induced Erk-Elk-1-SRE pathway. SPSB1 overexpression exhibited no effect on the basal level or epidermal growth factor-induced SRE-luciferase activity.
SPSB1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 231 amino acids (24-223 a.a.) and having a molecular mass of 26.1kDa.SPSB1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SSB1: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Belongs to the SPSB family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytosol Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: protein polyubiquitination |
| UniProt Code: | Q96BD6 |
| NCBI GenInfo Identifier: | 74731225 |
| NCBI Gene ID: | 80176 |
| NCBI Accession: | Q96BD6.1 |
| UniProt Secondary Accession: | Q96BD6,Q59FA1, Q5TIH9, Q9BRY9, Q9H6C5, A2A275, |
| UniProt Related Accession: | Q96BD6 |
| Molecular Weight: | Calculated MW: 30 kDaObserved MW: 31 kDa |
| NCBI Full Name: | SPRY domain-containing SOCS box protein 1 |
| NCBI Synonym Full Names: | splA/ryanodine receptor domain and SOCS box containing 1 |
| NCBI Official Symbol: | SPSB1�� |
| NCBI Official Synonym Symbols: | SSB1; SSB-1�� |
| NCBI Protein Information: | SPRY domain-containing SOCS box protein 1 |
| UniProt Protein Name: | SPRY domain-containing SOCS box protein 1 |
| Protein Family: | SPRY domain-containing SOCS box protein |
| UniProt Gene Name: | SPSB1�� |
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