Human SOX2 Recombinant Protein (RPPB4785)
- SKU:
- RPPB4785
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P48431
Description
| Product Name: | Human SOX2 Recombinant Protein |
| Product Code: | RPPB4785 |
| Size: | 25µg |
| Species: | Human |
| Target: | SOX2 |
| Synonyms: | MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in 2�PBS, pH 7.4 and 5% trehalose. |
| Solubility: | It is recommended to reconstitute the lyophilized Sox2 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Sox2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Sox2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by RP-HPLC and SDS-PAGE. |
| Amino Acid Sequence: | MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHMGGY GRKKRRQRRR |
SOX2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. SOX4 is important for early embryogenesis and for embryonic stem cell pluripotency.
Sox2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 330 amino acids (317 aa residues of the full length Sox2) and having a molecular mass of 36kDa.Sox2 is fused to a 13 amino acid TAT peptide at C-terminus (GGYGRKKRRQRRR) & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SOX2: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex Molecular Function:DNA binding; miRNA binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: cell cycle arrest; endodermal cell fate specification; eye development; forebrain development; inner ear development; negative regulation of epithelial cell proliferation; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; pituitary gland development; positive regulation of MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of caspase activity; regulation of gene expression; regulation of transcription, DNA-dependent; response to wounding; somatic stem cell maintenance Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
| NCBI Summary: | This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48431 |
| NCBI GenInfo Identifier: | 1351091 |
| NCBI Gene ID: | 6657 |
| NCBI Accession: | P48431.1 |
| UniProt Secondary Accession: | P48431,Q14537, |
| UniProt Related Accession: | P48431 |
| Molecular Weight: | 34kDa |
| NCBI Full Name: | Transcription factor SOX-2 |
| NCBI Synonym Full Names: | SRY-box 2 |
| NCBI Official Symbol: | SOX2�� |
| NCBI Official Synonym Symbols: | ANOP3; MCOPS3�� |
| NCBI Protein Information: | transcription factor SOX-2 |
| UniProt Protein Name: | Transcription factor SOX-2 |
| UniProt Gene Name: | SOX2�� |
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