Human SORBS3 Recombinant Protein (RPPB4778)

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SKU:
RPPB4778
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60504

Description

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Product Name:Human SORBS3 Recombinant Protein
Product Code:RPPB4778
Size:10µg
Species:Human
Target:SORBS3
Synonyms:Sorbin And SH3 Domain Containing 3, SCAM1, Vinexin Beta (SH3-Containing Adaptor Molecule-1), vinexin, SH3-Containing Adapter Molecule 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The SORBS3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMADGGSP FLGRRDFVYP SSTRDPSASN GGGSPARREE KKRKAARLKF DFQAQSPKEL TLQKGDIVYI HKEVDKNWLE GEHHGRLGIF PANYVEVLPA DEIPKPIKPP TYQVLEYGEA VAQYTFKGDL EVELSFRKGE HICLIRKVNE NWYEGRITGT GRQGIFPASY VQVSREPRLR LCDDGPQLPT SPRLTAAARS ARHPSSPSAL RSPADPIDLG GQTSPRRTGF SFPTQEPRPQ TQNLGTPGPA LSHSRGPSHP LDLGTSSPNT SQIHWTPYRA MYQYRPQNED ELELREGDRV DVMQQCDDGW FVGVSRRTQK FGTFPGNYVA PV

SORBS3 is an SH3 domain-containing adaptor protein. The existence of SH3 domains in the SORBS3 protein have a role in its capability to attach to other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Various transcript variants encoding different isoforms are known for this gene.

SORBS3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 352 amino acids (1-329) and having a molecular mass of 39.1 kDa. SORBS3 is fused to a 23 amino acid His-tag at N-terminus.

UniProt Protein Function:vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.Protein type: Motility/polarity/chemotaxis; Cell adhesion; Nuclear receptor co-regulator; Adaptor/scaffoldChromosomal Location of Human Ortholog: 8p21.3Cellular Component: cytoskeleton; cytosol; focal adhesion; nucleusMolecular Function: protein binding; structural constituent of cytoskeleton; transcription factor binding; vinculin bindingBiological Process: actin filament organization; cell adhesion; cell-substrate adhesion; muscle contraction; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytoskeleton organization and biogenesis; positive regulation of MAPKKK cascade; positive regulation of stress fiber formation
UniProt Protein Details:
NCBI Summary:This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:O60504
NCBI GenInfo Identifier:65301112
NCBI Gene ID:10174
NCBI Accession:NP_001018003.1
UniProt Secondary Accession:O60504,Q5BJE4, Q6NX54, Q96FY4, Q9UQE4
UniProt Related Accession:O60504
Molecular Weight:36,742 Da
NCBI Full Name:vinexin isoform 2
NCBI Synonym Full Names:sorbin and SH3 domain containing 3
NCBI Official Symbol:SORBS3��
NCBI Official Synonym Symbols:SCAM1; SH3D4; SCAM-1��
NCBI Protein Information:vinexin
UniProt Protein Name:Vinexin
UniProt Synonym Protein Names:SH3-containing adapter molecule 1; SCAM-1; Sorbin and SH3 domain-containing protein 3
Protein Family:Vinexin
UniProt Gene Name:SORBS3��
UniProt Entry Name:VINEX_HUMAN
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