Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6); idiopathic cardiomyopathy (IDC); sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.
Product Name:
Human SOD2/Mn-SOD Recombinant Protein (RPES0098)
Product Code:
RPES0098
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Superoxide Dismutase [Mn] Mitochondrial, SOD2
Accession:
P04179
Sequence:
Lys25-Lys222
Fusion tag:
N-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Superoxide Dismutase [Mn] Mitochondrial is produced by our E.coli expression system and the target gene encoding Lys25-Lys222 is expressed with a 6His tag at the N-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
23.7 kDa
AP Mol Mass:
23 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM Tris;100mM NaCl;50% glycerol;pH 8.0.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
