Human SNRPF Recombinant Protein (RPPB4761)

(No reviews yet) Write a Review
SKU:
RPPB4761

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human SNRPF Recombinant Protein
Product Code:RPPB4761
Size:20µg
Species:Human
Target:SNRPF
Synonyms:Sm-F, Sm protein F, snRNP-F, SMF, PBSCF, Small Nuclear Ribonucleoprotein Polypeptide F.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The SNRPF protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 1mM EDTA , and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE

SNRPF is a member of the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This type of common proteins have a crucial part in the biogenesis of the snRNPs. Moreover, they represent the major targets for the so-called anti-Sm auto-antibodies that are diagnostic for systemic lupus erythematosus (SLE). SNRPF assist in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex.

SNRPF produced in E.Coli is a single, non-glycosylated polypeptide chain containing 106 amino acids (1-86a.a.) and having a molecular mass of 11.8kDa.SNRPF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:snRNP F: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: cytosol; nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U1; spliceosome; U12-dependent spliceosome

Molecular Function:protein binding; RNA binding

Biological Process: histone mRNA metabolic process; nuclear import; nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosomal snRNP biogenesis; termination of RNA polymerase II transcription

UniProt Code:P62306
NCBI GenInfo Identifier:61237391
NCBI Gene ID:6636
NCBI Accession:P62306.1
UniProt Secondary Accession:P62306,Q15356, Q6IBQ1, Q6P4I0, A2VCR2, B2R498,
UniProt Related Accession:P62306
Molecular Weight:10kDa
NCBI Full Name:Small nuclear ribonucleoprotein F
NCBI Synonym Full Names:small nuclear ribonucleoprotein polypeptide F
NCBI Official Symbol:SNRPF��
NCBI Official Synonym Symbols:SMF; Sm-F; snRNP-F��
NCBI Protein Information:small nuclear ribonucleoprotein F
UniProt Protein Name:Small nuclear ribonucleoprotein F
UniProt Synonym Protein Names:Sm protein F; Sm-F; SmF
UniProt Gene Name:SNRPF��
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62306
View AllClose

Related Products