Human SNRPE Recombinant Protein (RPPB4760)

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SKU:
RPPB4760
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62304

Description

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Product Name:Human SNRPE Recombinant Protein
Product Code:RPPB4760
Size:5µg
Species:Human
Target:SNRPE
Synonyms:Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE, SNRPE, B-raf.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SNRPE solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN

SNRPE facilitates the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. While a core protein to UsnRNP, the SNRPE connects with the entire U family of snRNAs including U1�U6. In addition, SNRPE interacts with DDX20 and Small nuclear ribonucleoprotein polypeptide F.

SNRPE Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�112 amino acids (1-92 a.a.) and having a molecular mass of 12.9kDa. The SNRPE is purified by proprietary chromatographic techniques.

UniProt Protein Function:snRNP E: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.
UniProt Protein Details:

Protein type:Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: nucleoplasm; small nuclear ribonucleoprotein complex; spliceosome; U4/U6 x U5 tri-snRNP complex; snRNP U5; snRNP U2; snRNP U1; nucleus; cytosol; U12-dependent spliceosome

Molecular Function:protein binding; RNA binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis; RNA splicing; histone mRNA metabolic process; spliceosome assembly; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; hair cycle

Disease: Hypotrichosis 11

UniProt Code:P62304
NCBI GenInfo Identifier:61237380
NCBI Gene ID:6635
NCBI Accession:P62304.1
UniProt Secondary Accession:P62304,P08578, Q15498, Q5BKT2, B2R5B9,
UniProt Related Accession:P62304
Molecular Weight:92
NCBI Full Name:Small nuclear ribonucleoprotein E
NCBI Synonym Full Names:small nuclear ribonucleoprotein polypeptide E
NCBI Official Symbol:SNRPE��
NCBI Official Synonym Symbols:SME; Sm-E; B-raf; HYPT11��
NCBI Protein Information:small nuclear ribonucleoprotein E; snRNP-E; sm protein E
UniProt Protein Name:Small nuclear ribonucleoprotein E
UniProt Synonym Protein Names:Sm protein E; Sm-E; SmE
Protein Family:Small nuclear ribonucleoprotein
UniProt Gene Name:SNRPE��
UniProt Entry Name:RUXE_HUMAN
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