Human SNRPD1 Recombinant Protein (RPPB4755)

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RPPB4755

Description

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Product Name:Human SNRPD1 Recombinant Protein
Product Code:RPPB4755
Size:10µg
Species:Human
Target:SNRPD1
Synonyms:Small nuclear ribonucleoprotein Sm D1, Sm-D1, Sm-D autoantigen, snRNP core protein D1, SNRPD1, SMD1, SNRPD, HsT2456.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:SNRPD1 is supplied in 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.

SNRPD1 is a small nuclear ribonucleoprotein which is a member of the SNRNP core protein family. SNRPD1 may act as a charged protein scaffold to stimulate SNRNP assembly or strengthen SNRNP-SNRNP interactions via nonspecific electrostatic contacts with RNA. In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.

SNRPD1 Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 14,306 Dalton. SNRPD1 is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:snRNP D1: May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. Belongs to the snRNP core protein family.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U1; cytosol; nucleus; U12-dependent spliceosome

Molecular Function:protein binding; RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis; RNA splicing; spliceosome assembly; gene expression

NCBI Summary:This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Code:P62314
NCBI GenInfo Identifier:51338665
NCBI Gene ID:6632
NCBI Accession:P62314.1
UniProt Secondary Accession:P62314,P13641, B5BTZ1,
UniProt Related Accession:P62314
Molecular Weight:119
NCBI Full Name:Small nuclear ribonucleoprotein Sm D1
NCBI Synonym Full Names:small nuclear ribonucleoprotein D1 polypeptide 16kDa
NCBI Official Symbol:SNRPD1��
NCBI Official Synonym Symbols:SMD1; SNRPD; Sm-D1; HsT2456��
NCBI Protein Information:small nuclear ribonucleoprotein Sm D1; Sm-D autoantigen; snRNP core protein D1; small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene
UniProt Protein Name:Small nuclear ribonucleoprotein Sm D1
UniProt Synonym Protein Names:Sm-D autoantigen; snRNP core protein D1
Protein Family:Small nuclear ribonucleoprotein
UniProt Gene Name:SNRPD1��
UniProt Entry Name:SMD1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62314
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