Human SNRPB Recombinant Protein (RPPB4750)

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SKU:
RPPB4750
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P14678

Description

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Product Name:Human SNRPB Recombinant Protein
Product Code:RPPB4750
Size:10µg
Species:Human
Target:SNRPB
Synonyms:Small nuclear ribonucleoprotein-associated proteins B and B', snRNP-B, Sm protein B/B', Sm-B/B', SmB/B', SNRPB, COD, SNRPB1, SmB/SmB'.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:SNRPB is supplied in 20mM HEPES buffer pH-7.5, 0.01mM EDTA and 0.02% SDS.�
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.

SNRPB is one of several nuclear proteins which are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the SNRPB protein may also have a role in pre-mRNA splicing or snRNP structure. SNRPB binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. SNRPB functions in the U7 snRNP complex which is involved in histone 3'-end processing.

SNRPB Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 25.4 kDa which migrates at 30kDa on SDS-PAGE. SNRPB is expressed with a -6x His tag and purified by proprietary chromatographic techniques.

UniProt Protein Function:Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.
NCBI Summary:The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P14678
NCBI GenInfo Identifier:134037
NCBI Gene ID:6628
NCBI Accession:P14678.2
UniProt Secondary Accession:P14678,Q15490, Q6IB35, Q9UIS5,
UniProt Related Accession:P14678
Molecular Weight:30,032 Da
NCBI Full Name:Small nuclear ribonucleoprotein-associated proteins B and B'
NCBI Synonym Full Names:small nuclear ribonucleoprotein polypeptides B and B1
NCBI Official Symbol:SNRPB��
NCBI Official Synonym Symbols:COD; CCMS; SNRPB1; SmB/B'; Sm-B/B'; snRNP-B; SmB/SmB'��
NCBI Protein Information:small nuclear ribonucleoprotein-associated proteins B and B'
UniProt Protein Name:Small nuclear ribonucleoprotein-associated proteins B and B'
UniProt Synonym Protein Names:Sm protein B/B'; Sm-B/B'; SmB/B'
Protein Family:Small nuclear ribonucleoprotein-associated protein
UniProt Gene Name:SNRPB��
UniProt Entry Name:RSMB_HUMAN
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