Human SNAPC1 Recombinant Protein (RPPB4726)
- SKU:
- RPPB4726
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16533
Description
| Product Name: | Human SNAPC1 Recombinant Protein |
| Product Code: | RPPB4726 |
| Size: | 20µg |
| Species: | Human |
| Target: | SNAPC1 |
| Synonyms: | PTFgamma, SNAP43, snRNA-activating protein complexsubunit 1, SNAPc subunit 1, Proximal sequence element-binding transcriptionfactor subunit gamma, PSE-binding factor subunit gamma, PTF subunit gamma, Smallnuclear RNA-activating complex polypeptide 1, SNAPc 43 kDa subunit, SNAPC1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SNAPC1 protein solution (1mg/ml) contains 20mM Tris-HCl (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGTPPGL QTDCEALLSR FQETDSVRFE DFTELWRNMK FGTIFCGRMRNLEKNMFTKE ALALAWRYFL PPYTFQIRVG ALYLLYGLYN TQLCQPKQKI RVALKDWDEV LKFQQDLVNAQHFDAAYIFR KLRLDRAFHF TAMPKLLSYR MKKKIHRAEV TEEFKDPSDR VMKLITSDVL EEMLNVHDHYQNMKHVISVD KSKPDKALSL IKDDFFDNIK NIVLEHQQWH KDRKNPSLKS KTNDGEEKME GNSQETERCERAESLAKIKS KAFSVVIQAS KSRRHRQVKL DSSDSDSASG QGQVKATRKK EKKERLKPAG RKMSLRNKGNVQNIHKEDKP LSLSMPVITE EEENESLSGT EFTASKKRRK H |
Small Nuclear RNA Activating Complex, Polypeptide 1 (SNAPC1) is a part of the SNAPc complex necessary for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC1 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Moreover, SNAPC1 recruits TBP and BRF2 to the U6 snRNA TATA box.
SNAPC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 391 amino acids (1-368 a.a) and having a molecular mass of 45.4kDa.SNAPC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SNAPC1: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q22 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus; snRNA-activating protein complex Molecular Function:sequence-specific DNA binding Biological Process: snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter |
| UniProt Code: | Q16533 |
| NCBI GenInfo Identifier: | 8134716 |
| NCBI Gene ID: | 6617 |
| NCBI Accession: | Q16533.1 |
| UniProt Related Accession: | Q16533 |
| Molecular Weight: | 42,994 Da |
| NCBI Full Name: | snRNA-activating protein complex subunit 1 |
| NCBI Synonym Full Names: | small nuclear RNA activating complex polypeptide 1 |
| NCBI Official Symbol: | SNAPC1�� |
| NCBI Official Synonym Symbols: | SNAP43; PTFgamma�� |
| NCBI Protein Information: | snRNA-activating protein complex subunit 1 |
| UniProt Protein Name: | snRNA-activating protein complex subunit 1 |
| UniProt Synonym Protein Names: | Proximal sequence element-binding transcription factor subunit gamma; PSE-binding factor subunit gamma; PTF subunit gamma; Small nuclear RNA-activating complex polypeptide 1; snRNA-activating protein complex 43 kDa subunit; SNAPc 43 kDa subunit |
| Protein Family: | snRNA-activating protein complex |
| UniProt Gene Name: | SNAPC1�� |
| UniProt Entry Name: | SNPC1_HUMAN |
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