Human SNAI1 Recombinant Protein (RPPB4720)

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RPPB4720

Description

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Product Name:Human SNAI1 Recombinant Protein
Product Code:RPPB4720
Size:20µg
Species:Human
Target:SNAI1
Synonyms:Snail Family Zinc Finger 1, ProteinSna, Protein Snail Homolog 1, SNAH, Snail 1 (Drosophila Homolog), Zinc FingerProtein, Snail Homolog 1 (Drosophila), SLUGH2, SNA, SNAIL, SNAIL1, dJ710H13.1, Snail1 Homolog, Snail 1 Zinc Finger Protein, Snail 1, Zinc Finger Protein, SnailHomolog 1, Zinc Finger Protein SNAI1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SNAI1 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPRSFLV RKPSDPNRKP NYSELQDSNP EFTFQQPYDQ AHLLAAIPPPEILNPTASLP MLIWDSVLAP QAQPIAWASL RLQESPRVAE LTSLSDEDSG KGSQPPSPPS PAPSSFSSTSVSSLEAEAYA AFPGLGQVPK QLAQLSEAKD LQARKAFNCK YCNKEYLSLG ALKMHIRSHT LPCVCGTCGK AFSRPWLLQG HVRTHTGEKPFSCPHCSRAF ADRSNLRAHL QTHSDVKKYQ CQACARTFSR MSLLHKHQES GCSGCPR

Snailhomolog 1 (SNAI1) is involved in induction of the epithelial to mesenchymaltransition (EMT), formation and maintenance of embryonic mesoderm, growtharrest, survival and cell migration. SNAI1 binds to 3 E-boxes of the E-cadheringene promoterand represses its transcription. The nuclear protein encoded by SNAI1 isstructurally identical to the Drosophila snail protein, and is considered aswell to be vital for mesoderm formation in the developing embryo. At least twovariants of a similar processed pseudogene have been found on chromosome 2. Among the diseases associated with SNAI1 are waardenburgsyndrome type iid, and inappropriate adh syndrome.

SNAI1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-264 a.a) and having a molecular mass of 31.5kDa.SNAI1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Snail1: a protein of the C2H2-type zinc-finger family that regulates transcription. Involved in embryonic mesoderm formation. Plays a role in the epithelial to mesenchymal transition (EMT). EMT is characterized by decreased levels of the epithelial markers E-cadherin and alpha- and beta-catenin, and increased cellular migration and expression of the mesenchymal markers fibronectin, vimentin, N-cadherin and smooth muscle alpha-actin.E Snail binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. NF-kappaB binds and regulates the snail promoter and is critical for EMT, and inhibition of NF-kappaB activity lowered snail levels and morphologically reversed the EMT.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function:kinase binding; protein binding

Biological Process: epithelial to mesenchymal transition; mesoderm formation; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; positive regulation of cell migration; positive regulation of transcription, DNA-dependent

NCBI Summary:The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
UniProt Code:O95863
NCBI GenInfo Identifier:12644089
NCBI Gene ID:6615
NCBI Accession:O95863.2
UniProt Secondary Accession:O95863,Q9P113, Q9UBP7, Q9UHH7, B2R842,
UniProt Related Accession:O95863
Molecular Weight:29,083 Da
NCBI Full Name:Zinc finger protein SNAI1
NCBI Synonym Full Names:snail family transcriptional repressor 1
NCBI Official Symbol:SNAI1��
NCBI Official Synonym Symbols:SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1��
NCBI Protein Information:zinc finger protein SNAI1
UniProt Protein Name:Zinc finger protein SNAI1
UniProt Synonym Protein Names:Protein snail homolog 1; Protein sna
Protein Family:Protein snail
UniProt Gene Name:SNAI1��
UniProt Entry Name:SNAI1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95863
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