Human SMPDL3A Recombinant Protein (RPES1319)

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SKU:
RPES1319
Product Type:
Recombinant Protein
Species:
Human

Description

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Human SMPDL3A Recombinant Protein

Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene; with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols); regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems; revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.

Product Name:Human SMPDL3A Recombinant Protein (RPES1319)
Product Code:RPES1319
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Acid Sphingomyelinase-Like Phosphodiesterase 3a, ASM-Like Phosphodiesterase 3a,SMPDL3A,ASML3A
Accession:Q92484
Sequence:Leu23-Tyr453
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a is produced by our Mammalian expression system and the target gene encoding Leu23-Tyr453 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:49.9 kDa
AP Mol Mass:49.9 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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system_update_altDatasheetMouse SMPDL3A Recombinant Protein SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPD