Human SMCP Recombinant Protein (RPPB4718)

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SKU:
RPPB4718
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49901

Description

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Product Name:Human SMCP Recombinant Protein
Product Code:RPPB4718
Size:10µg
Species:Human
Target:SMCP
Synonyms:Sperm Mitochondria-Associated Cysteine-Rich Protein, MCSP, MCS, Mitochondrial Capsule Selenoprotein, HSMCSGEN1, Sperm Mitochondrial-Associated Cysteine-Rich Protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SMCP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol, 1mM EDTA and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMCDQTKH SKCCPAKGNQ CCPPQQNQCC QSKGNQCCPP KQNQCCQPKG SQCCPPKHNH CCQPKPPCCI QARCCGLETK PEVSPLNMES EPNSPQTQDK GCQTQQQPHS PQNESRPSK

SMCP is a protein-coding gene. SMCP localizes to the capsule linked with the mitochondrial outer membranes and assumed to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. Sperm mitochondria vary in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially construct a helical coiled sheath in the midpiece of the sperm flagellum. Diseases associated with SMCP include middle ear disease, and hard palate cancer.

SMCP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (1-116 a.a) and having a molecular mass of 15.2kDa (Molecular size on SDS-PAGE will appear higher). SMCP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SMCP: Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm; mitochondrion

Molecular Function:protein binding

Biological Process: penetration of zona pellucida; sperm motility

NCBI Summary:Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]
UniProt Code:P49901
NCBI GenInfo Identifier:20141463
NCBI Gene ID:4184
NCBI Accession:P49901.2
UniProt Secondary Accession:P49901,Q96A42,
UniProt Related Accession:P49901
Molecular Weight:12,767 Da
NCBI Full Name:Sperm mitochondrial-associated cysteine-rich protein
NCBI Synonym Full Names:sperm mitochondria associated cysteine rich protein
NCBI Official Symbol:SMCP��
NCBI Official Synonym Symbols:MCS; MCSP; HSMCSGEN1��
NCBI Protein Information:sperm mitochondrial-associated cysteine-rich protein
UniProt Protein Name:Sperm mitochondrial-associated cysteine-rich protein
Protein Family:Sperm mitochondrial-associated cysteine-rich protein
UniProt Gene Name:SMCP��
UniProt Entry Name:MCSP_HUMAN
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