Epigenetics & Nuclear Signaling Recombinant Proteins

Human SMAD1 Recombinant Protein (RPES5127)

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SKU:
RPES5127
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Epigenetics & Nuclear Signaling

Description

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Human SMAD1 Recombinant Protein

SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

Product Name:Human SMAD1 Recombinant Protein (RPES5127)
Product Code:RPES5127
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, Mothers Against DPP Homolog 1, JV4-1, Mad-Related Protein 1, SMAD Family Member 1,Transforming Growth Factor-Beta-Signaling Protein 1, BSP-1, SMAD1, BSP1, MADH1,SMAD 1,Smad1,hSMAD1,MADR1
Accession:Q15797
Sequence:Met 1-Ser465
Fusion tag:N-GST
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Mothers Against Decapentaplegic Homolog 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:78.7 kDa
AP Mol Mass:28&89 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0 .
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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