Immunology Recombinant Proteins
Human SLPI Recombinant Protein (RPES4128)
- SKU:
- RPES4128
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human SLPI Recombinant Protein
Secretory leukoprotease inhibitor (SLPI); also called antileukoprotease (ALP); is a 12-kDa; nonglycosylated serine protease inhibitor present in mucous secretions. It is thought to play a role in protecting the mucosae from injury associated with inflammation. SLPI is locally produced by serous cells; including bronchial submucosal glands. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites; and have been shown to be modulated in multiple pathological conditions. Elafin and SLPI are structurally related in that both have a fold with a four-disulfide core or whey acidic protein (WAP) domain responsible for inhibiting proteases. SLPI is a prominent innate immune protein of the respiratory tract; possessing serine protease inhibitor activity; antibacterial activity; and anti-inflammatory/immunomodulatory activity.
| Product Name: | Human SLPI Recombinant Protein (RPES4128) |
| Product Code: | RPES4128 |
| Size: | 100µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | ALK1,ALP,BLPI,HUSI,HUSI-I,MPI,WAP4,WFDC4 |
| Accession: | P03973 |
| Sequence: | Met 1-Ala132 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate; Mca-RPKPVE-Nval-WRK (Dnp)-NH2 (Catalog # ES002).The IC50 value is <1 Nm. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human SLPI (P03973)( Met1-Ala132) was expressed; with a C-terminal polyhistidine tag. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 13.1 kDa |
| AP Mol Mass: | 15 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris; 500mM NaCl; 10% gly; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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