Human SLC7A11 Full-Length Bioactive Membrane Protein (HDFP029)

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SKU:
HDFP029
Product Type:
Recombinant Protein
Protein Type:
Full-Length Bioactive Membrane Protein
Species:
Human
Uniprot:
Q9UPY5

Description

system_update_altDatasheet
Product nameHuman SLC7A11 full length protein-synthetic nanodisc
Size:10ug
Product SKU:HDFP029
Product CategoryFull Length Transmembrane Proteins
Target:SLC7A11
Uniprot:Q9UPY5
Description:Human SLC7A11 full length protein-synthetic nanodisc
Molecular Weight:The human full length SLC7A11 protein has a MW of 55.4 kDa
Protein Family:Druggable Genome, Transmembrane
Protein Pathways:
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Synonyms:CCBR1; xCT
Expression System:HEK293
Formulation:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Background:This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Delivery:3-4 weeks
UsageResearch use only
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