Human SLC51B Recombinant Protein (RPPB4708)

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SKU:
RPPB4708
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q86UW2

Description

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Product Name:Human SLC51B Recombinant Protein
Product Code:RPPB4708
Size:10µg
Species:Human
Target:SLC51B
Synonyms:OSTB, OSTBETA, Organic solute transporter subunit beta, OST-beta,Solute carrier family 51 subunit beta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SLC51Bprotein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glyceroland 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRSIQASR KEKMQPPEKE TPEVLHLDEA KDHNSLNNLR ETLLSEKPNLAQVELELKER DVLSVFLPDV PETES

Solute Carrier Family 51 Beta (SLC51B), is a protein coding gene. SLC51Bis an organic solute transporter subunit. SLC51 is composed of two different proteinsthat must heterodimerize to generate transport activity, however the role ofthe individual subunits inmediating transport activity is unknown. The results show that SLC51B isrequired for both proper trafficking of SLC51A and formation of the functional transportunit, and identify specific residues of SLC51B essential for these processes. Among the diseases associated with SLC51B areextrahepatic cholestasis, and biliary atresia.

SLC51B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 95 amino acids (57-128 a.a) and having a molecular mass of 10.7kDa.SLC51B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q86UW2
NCBI GenInfo Identifier:269914183
NCBI Gene ID:123264
NCBI Accession:NP_849190.2
UniProt Secondary Accession:Q86UW2,Q3SYF5
UniProt Related Accession:Q86UW2
Molecular Weight:14,346 Da
NCBI Full Name:organic solute transporter subunit beta
NCBI Synonym Full Names:solute carrier family 51 beta subunit
NCBI Official Symbol:SLC51B��
NCBI Official Synonym Symbols:OSTB; OSTBETA��
NCBI Protein Information:organic solute transporter subunit beta
UniProt Protein Name:Organic solute transporter subunit beta
UniProt Synonym Protein Names:Solute carrier family 51 subunit beta
Protein Family:
UniProt Gene Name:SLC51B��
UniProt Entry Name:
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