Human SLAMF7 Recombinant Protein (RPPB4705)

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SKU:
RPPB4705
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NQ25

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human SLAMF7 Recombinant Protein
Product Code:RPPB4705
Size:10µg
Species:Human
Target:SLAMF7
Synonyms:SLAMF7,SLAM Family Member 7, CD2-Like Receptor-Activating Cytotoxic Cells, Membrane Protein FOAP-12, CD2Subset 1, Protein 19A, CRACC, CS1, Novel LY9(Lymphocyte Antigen 9) Like Protein, CD2-Like Receptor Activating CytotoxicCells, 19A24 Protein, CD319 Antigen, Novel Ly9, CD319, 19A.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:SLAMF7 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:SGPVKELVGS VGGAVTFPLK SKVKQVDSIV WTFNTTPLVT IQPEGGTIIVTQNRNRERVD FPDGGYSLKL SKLKKNDSGI YYVGIYSSSL QQPSTQEYVL HVYEHLSKPK VTMGLQSNKNGTCVTNLTCC MEHGEEDVIY TWKALGQAAN ESHNGSILPI SWRWGESDMT FICVARNPVS RNFSSPILAR KLCEGAADDPDSSMLEHHHH HH

SLAMF7 belongs to the CS2 family of cell surface receptors. SLAMF7 is asingle-pass type 1 membrane protein, SLAMF7 Isoform 1 mediates NK cellactivation via a SH2D1A-independent extracellularsignal-regulated ERK-mediated pathway.SLAMF7 functions in lymphocyte adhesion.Furthermore, SLAMF7 can exert activatingof inhibitory influences on cells of the immune system depending on cellular context as well as the availability of effector proteins.

SLAMF7 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 212 amino acids (23-226a.a.) and having a molecular mass of 23.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). SLAMF7 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:SLAMF7: Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1-q24.1

Cellular Component: plasma membrane

Biological Process: regulation of immune response

UniProt Code:Q9NQ25
NCBI GenInfo Identifier:19923572
NCBI Gene ID:57823
NCBI Accession:NP_067004.3
UniProt Secondary Accession:Q9NQ25,Q8N6Y8, Q8ND32, Q9NY08, Q9NY23, A8K3U1, B4DPU4 B4DPY3, B4DWA3,
UniProt Related Accession:Q9NQ25
Molecular Weight:
NCBI Full Name:SLAM family member 7 isoform a
NCBI Synonym Full Names:SLAM family member 7
NCBI Official Symbol:SLAMF7��
NCBI Official Synonym Symbols:19A; CS1; CD319; CRACC��
NCBI Protein Information:SLAM family member 7; protein 19A; CD2 subset 1; 19A24 protein; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; novel LY9 (lymphocyte antigen 9) like protein
UniProt Protein Name:SLAM family member 7
UniProt Synonym Protein Names:CD2 subset 1; CD2-like receptor-activating cytotoxic cells; CRACC; Membrane protein FOAP-12; Novel Ly9; Protein 19A; CD_antigen: CD319
Protein Family:SLAM family
UniProt Gene Name:SLAMF7��
UniProt Entry Name:SLAF7_HUMAN
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system_update_altDatasheetHuman SLAMF7/CD319 Recombinant Protein SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed i