Human SLAMF6 Recombinant Protein (RPPB4703)
- SKU:
- RPPB4703
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96DU3
Description
| Product Name: | Human SLAMF6 Recombinant Protein |
| Product Code: | RPPB4703 |
| Size: | 20µg |
| Species: | Human |
| Target: | SLAMF6 |
| Synonyms: | CD352, KALI, KALIb, Ly108, NTB-A, NTBA, Activating NK receptor, SLAM family member 6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SLAMF6 protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSQSSLTPL MVNGILGESV TLPLEFPAGE KVNFITWLFN ETSLAFIVPH ETKSPEIHVT NPKQGKRLNF TQSYSLQLSN LKMEDTGSYR AQISTKTSAK LSSYTLRILR QLRNIQVTNH SQLFQNMTCE LHLTCSVEDA DDNVSFRWEA LGNTLSSQPN LTVSWDPRIS SEQDYTCIAE NAVSNLSFSV SAQKLCEDVK IQYTDTKM |
SLAM family member 6 (SLAMF6) is a member of the SLAM family of immune cell receptors. SLAMF6 is a unique receptor on T cells which, when triggered potentiates T cell expansion in a CD28-independent manner. SLAMF6 has a high expression on NK-, T-, and B cells. SLAMF6 exhibits homotypic interactions and can connect with adaptor molecules such as SAP to alter immune cell function.
SLAMF6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 228 amino acids (22-226 a.a.) and having a molecular mass of 25.5kDa. SLAMF6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; regulation of immune response |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] |
| UniProt Code: | Q96DU3 |
| NCBI GenInfo Identifier: | 205830927 |
| NCBI Gene ID: | 114836 |
| NCBI Accession: | Q96DU3.3 |
| UniProt Secondary Accession: | Q96DU3,Q14CF0, Q5TAS4, Q5TAS6, Q5TAT3, Q96DV0, A6NMW2 B2R8X8, |
| UniProt Related Accession: | Q96DU3 |
| Molecular Weight: | 24,976 Da |
| NCBI Full Name: | SLAM family member 6 |
| NCBI Synonym Full Names: | SLAM family member 6 |
| NCBI Official Symbol: | SLAMF6�� |
| NCBI Official Synonym Symbols: | KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000�� |
| NCBI Protein Information: | SLAM family member 6 |
| UniProt Protein Name: | SLAM family member 6 |
| UniProt Synonym Protein Names: | Activating NK receptor; NK-T-B-antigen; NTB-A; CD_antigen: CD352 |
| Protein Family: | SLAM family |
| UniProt Gene Name: | SLAMF6�� |
| UniProt Entry Name: | SLAF6_HUMAN |
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