Human SLA2 Recombinant Protein (RPPB4700)
- SKU:
- RPPB4700
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H6Q3
Description
| Product Name: | Human SLA2 Recombinant Protein |
| Product Code: | RPPB4700 |
| Size: | 20µg |
| Species: | Human |
| Target: | SLA2 |
| Synonyms: | Src-like-adapter 2, Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2, SLA2, C20orf156, SLAP2, Src-like-adapter 2 isoform a, Src-like-adaptor 2, C20orf156, MARS, SLAP-2, SLAP2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SLA2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGSLPSR RKSLPSPSLS SSVQGQGPVT MEAERSKATA VALGSFPAGG PAELSLRLGE PLTIVSEDGD WWTVLSEVSG REYNIPSVHV AKVSHGWLYE GLSREKAEEL LLLPGNPGGA FLIRESQTRR GSYSLSVRLS RPASWDRIRH YRIHCLDNGW LYISPRLTFP SLQALVDHYS ELADDICCLL KEPCVLQRAG PLPGKDIPLP VTVQRTPLNW KELDSSLLFS EAATGEESLL SEGLRESLSF YISLNDEAVS LDDA |
Src-Like-Adaptor 2, also known as SLA2, is a part of the SLAP family of adapter proteins. SLA2 acts as a significant receptor-proximal in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. SLA2 interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c.
SLA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 284 amino acids (1-261 a.a.) and having a molecular mass of 31kDa.SLA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SLAP2: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Vesicle Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: cytoplasm; plasma membrane Molecular Function:protein binding; protein N-terminus binding; SH3/SH2 adaptor activity Biological Process: antigen receptor-mediated signaling pathway; B cell mediated immunity; intracellular receptor-mediated signaling pathway; negative regulation of B cell activation; negative regulation of calcium-mediated signaling; negative regulation of transcription from RNA polymerase II promoter; T cell activation |
| NCBI Summary: | This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H6Q3 |
| NCBI GenInfo Identifier: | 30173374 |
| NCBI Gene ID: | 84174 |
| NCBI Accession: | Q9H6Q3.3 |
| UniProt Secondary Accession: | Q9H6Q3,Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135, A8K648 E1P5U1, E1P5U2, |
| UniProt Related Accession: | Q9H6Q3 |
| Molecular Weight: | 20,380 Da |
| NCBI Full Name: | Src-like-adapter 2 |
| NCBI Synonym Full Names: | Src like adaptor 2 |
| NCBI Official Symbol: | SLA2�� |
| NCBI Official Synonym Symbols: | MARS; SLAP2; SLAP-2; C20orf156�� |
| NCBI Protein Information: | src-like-adapter 2 |
| UniProt Protein Name: | Src-like-adapter 2 |
| UniProt Synonym Protein Names: | Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2 |
| Protein Family: | Src-like-adapter |
| UniProt Gene Name: | SLA2�� |
| UniProt Entry Name: | SLAP2_HUMAN |
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