Human SLA2 Recombinant Protein (RPPB4700)

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RPPB4700

Description

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Product Name:Human SLA2 Recombinant Protein
Product Code:RPPB4700
Size:20µg
Species:Human
Target:SLA2
Synonyms:Src-like-adapter 2, Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2, SLA2, C20orf156, SLAP2, Src-like-adapter 2 isoform a, Src-like-adaptor 2, C20orf156, MARS, SLAP-2, SLAP2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SLA2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGSLPSR RKSLPSPSLS SSVQGQGPVT MEAERSKATA VALGSFPAGG PAELSLRLGE PLTIVSEDGD WWTVLSEVSG REYNIPSVHV AKVSHGWLYE GLSREKAEEL LLLPGNPGGA FLIRESQTRR GSYSLSVRLS RPASWDRIRH YRIHCLDNGW LYISPRLTFP SLQALVDHYS ELADDICCLL KEPCVLQRAG PLPGKDIPLP VTVQRTPLNW KELDSSLLFS EAATGEESLL SEGLRESLSF YISLNDEAVS LDDA

Src-Like-Adaptor 2, also known as SLA2, is a part of the SLAP family of adapter proteins. SLA2 acts as a significant receptor-proximal in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. SLA2 interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c.

SLA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 284 amino acids (1-261 a.a.) and having a molecular mass of 31kDa.SLA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SLAP2: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: cytoplasm; plasma membrane

Molecular Function:protein binding; protein N-terminus binding; SH3/SH2 adaptor activity

Biological Process: antigen receptor-mediated signaling pathway; B cell mediated immunity; intracellular receptor-mediated signaling pathway; negative regulation of B cell activation; negative regulation of calcium-mediated signaling; negative regulation of transcription from RNA polymerase II promoter; T cell activation

NCBI Summary:This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H6Q3
NCBI GenInfo Identifier:30173374
NCBI Gene ID:84174
NCBI Accession:Q9H6Q3.3
UniProt Secondary Accession:Q9H6Q3,Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135, A8K648 E1P5U1, E1P5U2,
UniProt Related Accession:Q9H6Q3
Molecular Weight:20,380 Da
NCBI Full Name:Src-like-adapter 2
NCBI Synonym Full Names:Src like adaptor 2
NCBI Official Symbol:SLA2��
NCBI Official Synonym Symbols:MARS; SLAP2; SLAP-2; C20orf156��
NCBI Protein Information:src-like-adapter 2
UniProt Protein Name:Src-like-adapter 2
UniProt Synonym Protein Names:Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2
Protein Family:Src-like-adapter
UniProt Gene Name:SLA2��
UniProt Entry Name:SLAP2_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9H6Q3
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