Human SIRPG Recombinant Protein (RPPB4689)
- SKU:
- RPPB4689
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9P1W8
Description
| Product Name: | Human SIRPG Recombinant Protein |
| Product Code: | RPPB4689 |
| Size: | 20µg |
| Species: | Human |
| Target: | SIRPG |
| Synonyms: | signal-regulatory protein gamma isoform 1 precursor, bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma, Signal-Regulatory Protein Gamma, SIRPG, SIRP-b2, SIRP-beta-2, CD_antigen: CD172g, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-gamma. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SIRPG protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEEELQMI QPEKLLLVTV GKTATLHCTV TSLLPVGPVL WFRGVGPGRE LIYNQKEGHF PRVTTVSDLT KRNNMDFSIR ISSITPADVG TYYCVKFRKG SPENVEFKSG PGTEMALGAK PSAPVVLGPA ARTTPEHTVS FTCESHGFSP RDITLKWFKN GNELSDFQTN VDPTGQSVAY SIRSTARVVL DPWDVRSQVI CEVAHVTLQG DPLRGTANLS EAIRVPPTLE VTQQPMRVGN QVNVTCQVRK FYPQSLQLTW SENGNVCQRE TASTLTENKD GTYNWTSWFL VNISDQRDDV VLTCQVKHDG QLAVSKRLAL EVTVHQKDQS SDATP |
Signal-Regulatory Protein Gamma (SIRPG) belongs to the signal-regulatory protein (SIRP) family whose members are receptor-type transmembrane glycoproteins which negatively regulate the receptor tyrosine kinase-coupled signaling processes. SIRPG is also a part of the immunoglobulin superfamily.
SIRPG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 355 amino acids (29-360 a.a.) and having a molecular mass of 39.1kDa.SIRPG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. |
| NCBI Summary: | The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9P1W8 |
| NCBI GenInfo Identifier: | 124053651 |
| NCBI Gene ID: | 55423 |
| NCBI Accession: | Q9P1W8.3 |
| UniProt Secondary Accession: | Q9P1W8,Q5D051, Q5JV25, Q5MKL4, Q8WWA5, Q9NQK8, B1AKP6 |
| UniProt Related Accession: | Q9P1W8 |
| Molecular Weight: | 29,967 Da |
| NCBI Full Name: | Signal-regulatory protein gamma |
| NCBI Synonym Full Names: | signal regulatory protein gamma |
| NCBI Official Symbol: | SIRPG�� |
| NCBI Official Synonym Symbols: | CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma�� |
| NCBI Protein Information: | signal-regulatory protein gamma |
| UniProt Protein Name: | Signal-regulatory protein gamma |
| UniProt Synonym Protein Names: | CD172 antigen-like family member B; Signal-regulatory protein beta-2; SIRP-b2; SIRP-beta-2; CD_antigen: CD172g |
| Protein Family: | Signal-regulatory protein |
| UniProt Gene Name: | SIRPG�� |
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