Immune Checkpoint Recombinant Proteins

Human SIRPα Recombinant Protein (mFc Tag) (HDPT0178)

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SKU:
HDPT0178
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human SIRPα Recombinant Protein (mFc Tag)

Description:Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Product name:Human SIRPα Recombinant Protein (mFc Tag)
Synonyms:SHPS1, SIRPA, CD172A, BIT, MFR, MYD1, P84, PTPNS
Type:protein
Size:50 µg
Name:SIRPα
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Mouse Fc tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:SIRPα(Glu31-Arg370)+mFc(Pro99-Lys330)
Gene ID:140885
Uniprot:P78324
Molecular Weight:70-100 kDa
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