Cytokines Recombinant Proteins

Human sIL 6R Recombinant Protein (RPPB0534)

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SKU:
RPPB0534
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08887
Research Area:
Cytokines

Description

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Product Name:Human sIL 6R Recombinant Protein
Product Code:RPPB0534
Size:20µg
Species:Human
Target:sIL 6R
Synonyms:IL6R-alpha, CD126, IL-6R 1, CD126 antigen, IL6RA, Interleukin 6 receptor, Interleukin 6 receptor alpha subunit, Interleukin-6 receptor alpha chain precursor, B cell stimulatory factor-2,Membrane glycoprotein 80, gp80, IL-6R, MGC104991.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CD126 His-Tag protein is supplied in 20mM Tris-HCl, pH 8.0, 0.8M Urea & 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.

The IL-6 receptor complex is composed of two membrane glycoproteins: the low affinity receptor and the signaltransducing component. The soluble form of IL6R is found in the urine of healthy adult humans and the serum of HIV positive individuals, as well as in the cell culture supernatants of stimulated PBMC�s. This soluble form of IL6R results from either proteolytic cleavage from the membrane, or an isoform derived splice variant.

sIL-6R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (20-357) corresponding to the mature IL-6R protein, having a molecular weight of 42.25 kDa, with an aminoterminal hexahistidine tag.The sIL6R is purified by proprietary chromatographic techniques.

UniProt Protein Function:Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
NCBI Summary:This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
UniProt Code:P08887
NCBI GenInfo Identifier:124343
NCBI Gene ID:3570
NCBI Accession:P08887.1
UniProt Secondary Accession:P08887,Q16202, Q53EQ7, Q5FWG2, Q5VZ23, A8KAE8, B2R6V4
UniProt Related Accession:P08887
Molecular Weight:40,237 Da
NCBI Full Name:Interleukin-6 receptor subunit alpha
NCBI Synonym Full Names:interleukin 6 receptor
NCBI Official Symbol:IL6R��
NCBI Official Synonym Symbols:IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1��
NCBI Protein Information:interleukin-6 receptor subunit alpha
UniProt Protein Name:Interleukin-6 receptor subunit alpha
UniProt Synonym Protein Names:IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126
Protein Family:Interleukin-6 receptor
UniProt Gene Name:IL6R��
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